1,910 results found
  1. Scientific Publishing: Recognizing the importance of new tools and resources for research

    Randy Schekman, Detlef Weigel, Fiona M Watt
    eLife is introducing a new article type—called Tools and Resources—to highlight new experimental techniques, datasets, software tools and other resources.
    Editorial
    Formats available:
    • HTML
    • PDF
    1. Neuroscience

    Demixed principal component analysis of neural population data

    Dmitry Kobak, Wieland Brendel ... Christian K Machens
    A new data analysis tool provides a concise way of visualizing neural data that summarizes all the relevant features of the population response in a single figure.
    1. Neuroscience

    Visualization of currents in neural models with similar behavior and different conductance densities

    Leandro M Alonso, Eve Marder
    Visualization methods display the dynamics of the currents in conductance-based model neurons, and show how their contribution changes in response to perturbation.
    1. Cell Biology

    Viscoelastic properties of suspended cells measured with shear flow deformation cytometry

    Richard Gerum, Elham Mirzahossein ... Ben Fabry
    Under fluid shear, living cells deform elliptically, align in flow direction, and rotate, from which their frequency-dependent viscoelastic properties can be inferred.
    1. Physics of Living Systems

    Measuring ligand-cell surface receptor affinities with axial line-scanning fluorescence correlation spectroscopy

    Antonia Franziska Eckert, Peng Gao ... Gerd Ulrich Nienhaus
    A robust fluorescence microscopy-based data acquisition and analysis framework affords the precise measurement of cell surface receptor affinities toward their cognate ligands and their densities in live cells/tissues.
    1. Computational and Systems Biology
    2. Neuroscience

    Mapping circuit dynamics during function and dysfunction

    Srinivas Gorur-Shandilya, Elizabeth M Cronin ... Eve Marder
    Mapping spike patterns from a small identified circuit reveals the diversity and complexity of circuit dynamics across animals and in response to perturbations.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Pyphe, a python toolbox for assessing microbial growth and cell viability in high-throughput colony screens

    Stephan Kamrad, María Rodríguez-López ... Jürg Bähler
    An open-source python package for phenotype analyses provides a versatile, modular and user-friendly solution to determine complementary fitness-related traits from large-scale assays of microbial colonies.
    1. Computational and Systems Biology
    2. Neuroscience

    On the objectivity, reliability, and validity of deep learning enabled bioimage analyses

    Dennis Segebarth, Matthias Griebel ... Robert Blum
    A comparison of different bioimage analysis pipelines reveals how deep learning can be used for automatized and reliable analysis of fluorescent features in biological datasets.
    1. Neuroscience

    Bayesian analysis of phase data in EEG and MEG

    Sydney Dimmock, Cian O'Donnell, Conor Houghton
    A Bayesian model of phase angles illustrates a novel approach to the analysis of phase coherence in frequency-tagged experiments.
    1. Computational and Systems Biology
    2. Neuroscience

    Training deep neural density estimators to identify mechanistic models of neural dynamics

    Pedro J Gonçalves, Jan-Matthis Lueckmann ... Jakob H Macke
    Deep neural networks can be trained to automatically find mechanistic models which quantitatively agree with experimental data, providing new opportunities for building and visualizing interpretable models of neural dynamics.

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