6,741 results found
    1. Cell Biology
    2. Cancer Biology

    Defective apical extrusion signaling contributes to aggressive tumor hallmarks

    Yapeng Gu, Jill Shea ... Jody Rosenblatt
    Disrupting extrusion, a process that drives epithelial cell death, leads to increased cell survival, poor barrier function, and enhanced cell invasion and, thereby, promotes tumor initiation and progression.
    1. Chromosomes and Gene Expression
    2. Physics of Living Systems

    Chromosome organization by one-sided and two-sided loop extrusion

    Edward J Banigan, Aafke A van den Berg ... Leonid A Mirny
    Seemingly contradictory findings of single-molecule and in vivo experiments on a major mechanism of chromosome organization are reconciled by computationally investigating mechanisms of loop extrusion that are consistent with both.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Local chromatin fiber folding represses transcription and loop extrusion in quiescent cells

    Sarah G Swygert, Dejun Lin ... Toshio Tsukiyama
    Using a yeast model of quiescence, it was demonstrated that dramatic changes in local chromatin fiber folding can occur under physiological conditions to regulate cellular processes.
    1. Developmental Biology

    Pitx2c orchestrates embryonic axis extension via mesendodermal cell migration

    Michelle M Collins, Hans-Martin Maischein ... Didier YR Stainier
    Expression of Pitx2c at the onset of gastrulation drives convergence and extension movements in the zebrafish embryo by promoting downstream pathways affecting chemokine signaling, integrin-ECM interactions, and planar cell polarity components.
    1. Developmental Biology

    A novel mechanism of gland formation in zebrafish involving transdifferentiation of renal epithelial cells and live cell extrusion

    Richard W Naylor, Hao-Han G Chang ... Alan J Davidson
    A rare example of direct transdifferentiation is discovered in zebrafish in which kidney epithelial cells change into an endocrine gland and undergo live-cell extrusion from the renal tubule.
    1. Genetics and Genomics

    Ether lipid biosynthesis promotes lifespan extension and enables diverse pro-longevity paradigms in Caenorhabditis elegans

    Lucydalila Cedillo, Fasih M Ahsan ... Alexander A Soukas
    Increased production of ether lipids is required to extend lifespan in response to metformin, phenformin, and multiple, distinct, longevity-promoting manipulations, illuminating the possibility that raising ether lipid levels represents a new therapeutic strategy to support healthy aging.
    1. Chromosomes and Gene Expression
    2. Physics of Living Systems

    The interplay between asymmetric and symmetric DNA loop extrusion

    Edward J Banigan, Leonid A Mirny
    Models of chromosome compaction by condensins demonstrate that two-sided loop extrusion and long residence times are required for high compaction, suggesting a tight coupling between these two properties in vivo.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    A Brownian ratchet model for DNA loop extrusion by the cohesin complex

    Torahiko L Higashi, Georgii Pobegalov ... Frank Uhlmann
    A structure-based model of the chromosomal cohesin complex, accompanied by molecular-mechanistic simulations, explains cohesin's key role in topologically entrapping DNA, as well as its ability to alternatively extrude DNA loops.
    1. Developmental Biology

    The E3 ubiquitin ligase mindbomb1 controls planar cell polarity-dependent convergent extension movements during zebrafish gastrulation

    Vishnu Muraleedharan Saraswathy, Akshai Janardhana Kurup ... Maximilian Fürthauer
    Mindbomb1 acts independently of it well-known role in Notch signalling to control the endocytic internalization of the Wnt co-receptor Ryk and thereby modulate the activity of the Planar Cell Polarity pathway that governs morphogenetic movements during embryonic development.
    1. Structural Biology and Molecular Biophysics

    Slowly folding surface extension in the prototypic avian hepatitis B virus capsid governs stability

    Cihan Makbul, Michael Nassal, Bettina Böttcher
    Duck Hepatitis B core protein forms capsids with a slowly folding extension domain which folding competence is important for viral replication.

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