591 results found
    1. Ecology

    A fitness trade-off between seasons causes multigenerational cycles in phenotype and population size

    Gustavo S Betini, Andrew G McAdam ... D Ryan Norris
    Seasonal variation in resources causes opposing episodes of selection on body size, which interact with density dependence to influence population dynamics.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Evolutionary stability of collateral sensitivity to antibiotics in the model pathogen Pseudomonas aeruginosa

    Camilo Barbosa, Roderich Römhild ... Hinrich Schulenburg
    Evolutionary trade-offs enhance efficacy of antibiotic therapy by constraining bacterial adaptation in dependence of drug order and trade-off effect size.
    1. Evolutionary Biology
    2. Neuroscience

    Natural variation in the Caenorhabditis elegans egg-laying circuit modulates an intergenerational fitness trade-off

    Laure Mignerot, Clotilde Gimond ... Christian Braendle
    Caenorhabditis elegans egg-laying behaviour shows pronounced variation in natural populations, making it a promising model to investigate the microevolution of a simple neural circuit.
    1. Evolutionary Biology

    The population genetics of collateral resistance and sensitivity

    Sarah M Ardell, Sergey Kryazhimskiy
    A theoretical model that considers the diversity of collateral effects among drug resistance mutations provides insights into the development of robust sequential antibiotic treatments.
    1. Computational and Systems Biology

    A unified framework for measuring selection on cellular lineages and traits

    Shunpei Yamauchi, Takashi Nozoe ... Yuichi Wakamoto
    A unified framework for cell lineage statistics enables quantification of fitness landscapes and selection strength for any cellular lineage traits in a model-independent manner, and reveals the contributions of growth heterogeneity to population growth in diverse experimental model systems.
    1. Ecology
    2. Microbiology and Infectious Disease

    Adaptability of non-genetic diversity in bacterial chemotaxis

    Nicholas W Frankel, William Pontius ... Thierry Emonet
    An experimentally constrained model shows that Escherichia coli faces fitness trade-offs in chemotaxis behaviors, and that adaptation of phenotypic diversity through altered gene regulation permits populations to resolve these trade-offs.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Intrinsic adaptive value and early fate of gene duplication revealed by a bottom-up approach

    Guillermo Rodrigo, Mario A Fares
    Gene duplication is a useful strategy to reduce intrinsic noise in gene expression, which can provide a selective advantage in scenarios of cost-benefit analysis of expression.
    1. Epidemiology and Global Health
    2. Evolutionary Biology

    A transmission-virulence evolutionary trade-off explains attenuation of HIV-1 in Uganda

    François Blanquart, Mary Kate Grabowski ... Christophe Fraser
    Analysis of epidemiological data reveals that viral loads in newly HIV-1 infected individuals in Uganda have declined for two decades, and evolutionary modelling shows that attenuation of the virus explains this decline.
    1. Evolutionary Biology

    Modeling the consequences of the dikaryotic life cycle of mushroom-forming fungi on genomic conflict

    Benjamin Auxier, Tamás L Czárán, Duur K Aanen
    Fungi that produce mushrooms have a unique life cycle with two haploid nuclei, instead of a diploid nucleus, this allows additional matings and selection at the level of the nucleus, even with a fitness trade-off.
    1. Evolutionary Biology

    Fitness variation across subtle environmental perturbations reveals local modularity and global pleiotropy of adaptation

    Grant Kinsler, Kerry Geiler-Samerotte, Dmitri A Petrov
    A set of adaptive mutations affect only a small number of phenotypes that matter in the evolution condition, and yet contain substantial latent functional diversity revealed in distant environments.

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