Thibaud Dieudonné, Sara Abad Herrera ... Guillaume Lenoir
Single particle cryo-electron microscopy associated with functional studies reveal a critical role of N- and C-terminal tails in the autoinhibition of the disease-related ATP8B1-CDC50A lipid flippase, the possible role of phosphorylation in autoinhibition relief, and strong activation by PI(3,4,5)P3.
Christoph J Slavetinsky, Janna N Hauser ... Andreas Peschel
Blocking the bacterial lipid flippase MprF by monoclonal antibodies enhance staphylococcal clearance by host defense and antibiotics providing a novel proof of concept for antivirulence approaches targeting bacterial resistance mechanisms.
Christoph Heier, Oskar Knittelfelder ... Ronald P Kühnlein
An ancestral enzyme tailors allocation of essential lipid resources to the progeny and connects maternal and embryonic sterol metabolism for reproductive success.
Simon Mysling, Kristian Kølby Kristensen ... Michael Ploug
Intravascular triglyceride hydrolysis by lipoprotein lipase is crucial for delivering lipid nutrients to vital tissues, such as the heart, skeletal muscle, and adipose tissue.
Olga Martzoukou, Sotiris Amillis ... George Diallinas
In filamentous fungi the AP-2 complex, which in mammals is an adaptor of clathrin-mediated endocytosis, is recruited to specific clathrin-independent apical endocytosis necessary for proper lipid maintenance and polar growth.
The GARP complex is important for the endocytic recycling of amino phospholipid flippases and cell wall proteins, and thus membrane and lipid organization in yeast.
Acyloxyacyl hydrolase, the host lipase that detoxifies bacterial lipopolysaccharides, also deacylates oxidized phospholipids, preventing inflammasome activation in macrophages in vitro and ameliorating acute lung injury in vivo.
Simon Mysling, Kristian Kølby Kristensen ... Michael Ploug
Building on previous work (Mysling et al., 2016), it is shown that angiopoietin-like protein 4 (ANGPTL4) inhibits lipoprotein lipase activity by catalyzing the unfolding of its hydrolase domain.
Suneeta Chimalapati, Marcela de Souza Santos ... Kim Orth
Considering the course of a pathogen's evolution, there appears to be interplay between secretion systems, providing unique, synergistic mechanisms to support a successful lifestyle for possibly pathogenesis, symbiosis and/or parasitosis.