60 results found
    1. Computational and Systems Biology

    Mitochondrial dysfunction remodels one-carbon metabolism in human cells

    Xiaoyan Robert Bao, Shao-En Ong ... Vamsi K Mootha
    Mitochondrial respiratory chain dysfunction inhibits mitochondrial one-carbon metabolism, impairing cellular nucleotide biosynthesis.
    1. Neuroscience

    Metabolic stress is a primary pathogenic event in transgenic Caenorhabditis elegans expressing pan-neuronal human amyloid beta

    Emelyne Teo, Sudharshan Ravi ... Jan Gruber
    Metabolic defects following expression of Aβ1-42 in nematode neurons are partially caused by inactivation of alpha-ketoglutarate dehydrogenase and can be rescued by Metformin.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Translational control of one-carbon metabolism underpins ribosomal protein phenotypes in cell division and longevity

    Nairita Maitra, Chong He ... Michael Polymenis
    Extensive molecular profiling shows how loss of highly similar, paralogous ribosomal proteins lead to distinct phenotypic outputs, through translational control of specific mRNAs.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    SIMMER employs similarity algorithms to accurately identify human gut microbiome species and enzymes capable of known chemical transformations

    Annamarie E Bustion, Renuka R Nayak ... Katherine S Pollard
    Computational reaction representations and profile hidden Markov model searches of metagenomics databases can be harnessed to accurately predict bacterial species and enzyme sequences responsible for biotransformations in the human gut microbiome.
    1. Computational and Systems Biology

    Essential metabolism for a minimal cell

    Marian Breuer, Tyler M Earnest ... Zaida Luthey-Schulten
    A near-complete flux balance analysis model of a minimal cell demonstrates the high essentiality of its metabolic genes, agrees well with experimental essentiality data and suggests some further gene removals.
    1. Cancer Biology
    2. Cell Biology

    Metabolic clogging of mannose triggers dNTP loss and genomic instability in human cancer cells

    Yoichiro Harada, Yu Mizote ... Naoyuki Taniguchi
    Proteomic and metabolomic analyses reveal how mannose exerts its anticancer activity.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    A tRNA modification balances carbon and nitrogen metabolism by regulating phosphate homeostasis

    Ritu Gupta, Adhish S Walvekar ... Sunil Laxman
    The role of an amino acid-dependent tRNA modification as a nutrient sensor and regulator of metabolic homeostasis has been discovered.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Caenorhabditis elegans methionine/S-adenosylmethionine cycle activity is sensed and adjusted by a nuclear hormone receptor

    Gabrielle E Giese, Melissa D Walker ... Albertha JM Walhout
    Metabolic activity of the methionine/S-adenosylmethionine cycle is sensed and transcriptionally regulated by a nuclear hormone receptor in Caenorhabditis elegans in order to maintain metabolic homeostasis in a tightly controlled regime.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Modeling the metabolic interplay between a parasitic worm and its bacterial endosymbiont allows the identification of novel drug targets

    David M Curran, Alexandra Grote ... John Parkinson
    A genome scale model of Brugia malayi metabolism illustrates a dynamic reliance on energy production pathways across its life cycle and identifies new drugs with experimentally supported anti-parasitic properties.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Plasmodium falciparum parasites deploy RhopH2 into the host erythrocyte to obtain nutrients, grow and replicate

    Natalie A Counihan, Scott A Chisholm ... Tania F de Koning-Ward
    Plasmodium parasites secrete RhopH2 from the rhoptry organelle into their host red blood cell to facilitate the uptake of essential nutrients required for parasite replication and survival.

Refine your results by:

Type
Research categories