517 results found
    1. Evolutionary Biology

    New footprints from Laetoli (Tanzania) provide evidence for marked body size variation in early hominins

    Fidelis T Masao, Elgidius B Ichumbaki ... Giorgio Manzi
    Bipedal footprints made 3.66 million years ago provide the clearest available evidence to date of the occurrence of marked body size variation in Australopithecus afarensis..
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Thousands of novel translated open reading frames in humans inferred by ribosome footprint profiling

    Anil Raj, Sidney H Wang ... Jonathan K Pritchard
    Over 7,000 novel translated sequences have been identified from human cells, including several hundred in annotated noncoding RNA, pseudogenes and de novo assembled transcripts.
    1. Structural Biology and Molecular Biophysics

    Piezo’s membrane footprint and its contribution to mechanosensitivity

    Christoph A Haselwandter, Roderick MacKinnon
    Membrane mechanics predict that the ion channel Piezo recruits the surrounding membrane to amplify its sensitivity to changes in membrane tension, with greatest sensitivity in the low-tension regime.
    1. Evolutionary Biology

    Evolutionary footprints of a cold relic in a rapidly warming world

    Eva Wolf, Emmanuel Gaquerel ... Marcus A Koch
    Evolutionary dynamics of polyploid plants of the genus Cochlearia during past periods of rapid climate change indicate increased rates of speciation and diversification in response to pronounced glacial cycles and cold periods in particular.
    1. Physics of Living Systems

    Deciphering the regulatory genome of Escherichia coli, one hundred promoters at a time

    William T Ireland, Suzannah M Beeler ... Rob Phillips
    A combination of massively parallel reporter assays and mass spectrometry uncovers the regulation of previously unexplored promoters across the Escherichia coli genome.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The genomic footprint of social stratification in admixing American populations

    Alex Mas-Sandoval, Sara Mathieson, Matteo Fumagalli
    Social hierarchies resulting from the European colonization of the Americas stratified the population structure, leading to ancestry-related assortative mating and sex bias patterns that can be inferred from the genomes of the populations across the continent.
    1. Evolutionary Biology

    A multidisciplinary approach to a unique palaeolithic human ichnological record from Italy (Bàsura Cave)

    Marco Romano, Paolo Citton ... Marco Avanzini
    Traces of crawling locomotion, including children younger than 3 years old, are documented for the first time in the global human ichnological record.
  1. Point of View: How scientists can reduce their carbon footprint

    Jeremy Nathans, Peter Sterling
    Cutting down on long-distance air travel is the best way to reduce the emission of greenhouse gases by the scientific community.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Distinct stages of the translation elongation cycle revealed by sequencing ribosome-protected mRNA fragments

    Liana F Lareau, Dustin H Hite ... Patrick O Brown
    The size of the mRNA fragment protected by a ribosome depends on the ribosome's conformation, which enables studies of the distinct steps of decoding and translocation at single-codon resolution.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Extensive translation of small Open Reading Frames revealed by Poly-Ribo-Seq

    Julie L Aspden, Ying Chen Eyre-Walker ... Juan-Pablo Couso
    Thousands of small Open Reading Frames are translated, and form two distinct classes based on their translational efficiency and bioinformatic indicators.

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