Erin A Bassett, Nicholas Tokarew ... Valerie A Wallace
The earliest steps of tumor initiation in the cerebellum are regulated by critical interactions between pre-tumor cells and stromal cells, which can be manipulated by targeting the Norrin/Frizzled4 signaling axis.
Wenchang Zhou, Giacomo Fiorin ... José D Faraldo-Gómez
The conformational mechanism of a transporter protein is found to have profound and energetically costly effects on the morphology of the surrounding membrane.
Sandra Gattas, Gabriel A Elias ... Norbert J Fortin
The hippocampal CA1 20–40 Hz rhythm is associated with nonspatial sequence memory processing and may contribute to the role of the hippocampus in processing temporal relationships among events.
Dopaminergic medication has differential effects on the discovered electrophysiological networks, which could be used to develop new electrical and pharmacological interventions in Parkinson’s disease.
Jennifer M Lin, Tyler A Mitchell ... Paolo Emanuele Forni
In vivo genetic experiments show that aberrant expression of a transcription factor can compromise the functionality of neurons which is important to better understand the potential mechanisms underlying neuropathologies.
Robert McCoy Vernon, Paul Andrew Chong ... Julie Deborah Forman-Kay
Statistics on the frequencies of pi interactions in folded protein structures enable successful prediction of intrinsically disordered protein phase separation, with clear implications for a physical understanding of cellular organization.
In the cytosol, the proteins constituting cell-matrix adhesion sites form multi-protein building blocks which enter and leave these sites unaltered, thereby contributing to their rapid and correct self-assembly.