10,424 results found
    1. Neuroscience

    How spatial release from masking may fail to function in a highly directional auditory system

    Norman Lee, Andrew C Mason
    The auditory periphery of Ormia ochracea does not allow for spatial release from masking.
    1. Cancer Biology
    2. Developmental Biology

    Norrin/Frizzled4 signalling in the preneoplastic niche blocks medulloblastoma initiation

    Erin A Bassett, Nicholas Tokarew ... Valerie A Wallace
    The earliest steps of tumor initiation in the cerebellum are regulated by critical interactions between pre-tumor cells and stromal cells, which can be manipulated by targeting the Norrin/Frizzled4 signaling axis.
    1. Structural Biology and Molecular Biophysics

    Large-scale state-dependent membrane remodeling by a transporter protein

    Wenchang Zhou, Giacomo Fiorin ... José D Faraldo-Gómez
    The conformational mechanism of a transporter protein is found to have profound and energetically costly effects on the morphology of the surrounding membrane.
    1. Neuroscience

    Proximal CA1 20–40 Hz power dynamics reflect trial-specific information processing supporting nonspatial sequence memory

    Sandra Gattas, Gabriel A Elias ... Norbert J Fortin
    The hippocampal CA1 20–40 Hz rhythm is associated with nonspatial sequence memory processing and may contribute to the role of the hippocampus in processing temporal relationships among events.
    1. Neuroscience

    Differential dopaminergic modulation of spontaneous cortico–subthalamic activity in Parkinson’s disease

    Abhinav Sharma, Diego Vidaurre ... Esther Florin
    Dopaminergic medication has differential effects on the discovered electrophysiological networks, which could be used to develop new electrical and pharmacological interventions in Parkinson’s disease.
    1. Neuroscience

    Neural pattern change during encoding of a narrative predicts retrospective duration estimates

    Olga Lositsky, Janice Chen ... Kenneth A Norman
    Judgments of how much time elapsed between two events in a story are predicted by changes in fMRI activity patterns.
    1. Developmental Biology
    2. Neuroscience

    Sociosexual behavior requires both activating and repressive roles of Tfap2e/AP-2ε in vomeronasal sensory neurons

    Jennifer M Lin, Tyler A Mitchell ... Paolo Emanuele Forni
    In vivo genetic experiments show that aberrant expression of a transcription factor can compromise the functionality of neurons which is important to better understand the potential mechanisms underlying neuropathologies.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Pi-Pi contacts are an overlooked protein feature relevant to phase separation

    Robert McCoy Vernon, Paul Andrew Chong ... Julie Deborah Forman-Kay
    Statistics on the frequencies of pi interactions in folded protein structures enable successful prediction of intrinsically disordered protein phase separation, with clear implications for a physical understanding of cellular organization.
    1. Cell Biology

    Symmetric exchange of multi-protein building blocks between stationary focal adhesions and the cytosol

    Jan-Erik Hoffmann, Yessica Fermin ... Eli Zamir
    In the cytosol, the proteins constituting cell-matrix adhesion sites form multi-protein building blocks which enter and leave these sites unaltered, thereby contributing to their rapid and correct self-assembly.
    1. Stem Cells and Regenerative Medicine
    2. Chromosomes and Gene Expression

    Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation

    Marc A Kerenyi, Zhen Shao ... Stuart H Orkin
    Lysine-specific demethylase 1 (Lsd1) has an essential role during both the early and later stages of blood cell development.

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