249 results found
    1. Neuroscience

    APP modulates KCC2 expression and function in hippocampal GABAergic inhibition

    Ming Chen, Jinzhao Wang ... Li Yang
    APP interacts with KCC2 to limit the latter from tyrosine-phosphorylation and ubiquitination and thus subsequent degradation, revealing a novel molecular pathway in which APP regulates GABAergic signaling and thus inhibition in the hippocampus.
    1. Neuroscience

    Excitation of medium spiny neurons by ‘inhibitory’ ultrapotent chemogenetics via shifts in chloride reversal potential

    Stephanie C Gantz, Maria M Ortiz ... Khaled Moussawi
    Modifying membrane potential by an 'inhibitory' chloride conductance such as PSAM4-GlyR is inherently unstable because the normally low intracellular concentration of chloride is readily increased by influx of chloride.
    1. Developmental Biology
    2. Neuroscience

    The NKCC1 antagonist bumetanide mitigates interneuronopathy associated with ethanol exposure in utero

    Alexander GJ Skorput, Stephanie M Lee ... Hermes H Yeh
    Prenatal ethanol exposure results in aberrant tangential migration by altering NKCC1-mediated chloride homeostasis that can be mitigated by bumetanide.
    1. Neuroscience

    The adipocyte hormone leptin sets the emergence of hippocampal inhibition in mice

    Camille Dumon, Diabe Diabira ... Jean-Luc Gaiarsa
    Maternal obesity and excess of the adipocyte hormone leptin delays the emergence of synaptic inhibition in the developing brain mice.
    1. Computational and Systems Biology
    2. Neuroscience

    Nonlinearities between inhibition and T-type calcium channel activity bidirectionally regulate thalamic oscillations

    Adam C Lu, Christine Kyuyoung Lee ... Mark P Beenhakker
    A multi-scale integration of experimental and computational approaches shows how a non-linear dependence of T-type calcium channel gating on GABAB receptor activity regulates thalamic network oscillations.
    1. Neuroscience

    Dendritic Na+ spikes enable cortical input to drive action potential output from hippocampal CA2 pyramidal neurons

    Qian Sun, Kalyan V Srinivas ... Steven A Siegelbaum
    In the hippocampus, dendritic Na + spikes are required for signals from the entorhinal cortex to drive action potentials in CA2-but not CA1 or CA3-pyramidal neurons.
    1. Neuroscience

    Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition

    Vivek Mahadevan, C Sahara Khademullah ... Melanie A Woodin
    Unbiased functional proteomics reveal that protein interactions are a key regulator of the strength of synaptic inhibition in neurons of the central nervous system.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Delta glutamate receptor conductance drives excitation of mouse dorsal raphe neurons

    Stephanie C Gantz, Khaled Moussawi, Holly S Hake
    In mouse brain slices, native delta glutamate receptors carry ionic current and underlie the α1-adrenergic receptor-mediated depolarization of dorsal raphe neurons that drives action potential firing in vivo.
    1. Neuroscience

    Robust perisomatic GABAergic self-innervation inhibits basket cells in the human and mouse supragranular neocortex

    Viktor Szegedi, Melinda Paizs ... Karri Lamsa
    Abundant self-inhibitory synapses in the layer 2/3 of human neocortex strongly regulate the function of basket cells.
    1. Neuroscience

    Astrocytic modulation of excitatory synaptic signaling in a mouse model of Rett syndrome

    Benjamin Rakela, Paul Brehm, Gail Mandel
    Astrocytes impact neuronal signaling in brain dependent on status of the transcriptional repressor, Methyl CpG Binding Protein 2.

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