23 results found
    1. Biochemistry and Chemical Biology
    2. Ecology

    De novo synthesis of a sunscreen compound in vertebrates

    Andrew R Osborn, Khaled H Almabruk ... Taifo Mahmud
    Many vertebrates are able to synthesize a sunscreen compound de novo and the pathway involved can be used for heterologous production of the compound in yeast.
    1. Ecology
    2. Biochemistry and Chemical Biology

    Biochemistry: Shedding light on sunscreen biosynthesis in zebrafish

    Carolyn A Brotherton, Emily P Balskus
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    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Memory CD4 T cell subsets are kinetically heterogeneous and replenished from naive T cells at high levels

    Graeme Gossel, Thea Hogan ... Andrew J Yates
    The maintenance of memory CD4 T cells in mice relies on a continual and strikingly high level of replenishment from naive precursors, and older memory T cells may resist the influx of newer ones.
    1. Immunology and Inflammation

    The HIV-1 latent reservoir is largely sensitive to circulating T cells

    Joanna A Warren, Shuntai Zhou ... Nilu Goonetilleke
    HIV-specific T cells remain detectable for years in HIV-infected individuals on antiretroviral therapy and importantly, mostly (68%) recognize HIV viruses that have the capacity to rebound following treatment interruption.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Sweepstakes reproductive success via pervasive and recurrent selective sweeps

    Einar Árnason, Jere Koskela ... Bjarki Eldon
    Selective sweepstakes from pervasive positive selection, rather than demographic changes or random sweepstakes reproduction, is the primary determinant of reproductive skew and genetic diversity in the highly prolific Atlantic cod.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Cell-to-cell infection by HIV contributes over half of virus infection

    Shingo Iwami, Junko S Takeuchi ... Kei Sato
    The human immunodeficiency virus HIV-1 primarily spreads between cells using a method called cell-to-cell infection, suggesting that this process may be a target for anti-viral drugs.
    1. Developmental Biology
    2. Evolutionary Biology

    A novel cis-regulatory element drives early expression of Nkx3.2 in the gnathostome primary jaw joint

    Jake Leyhr, Laura Waldmann ... Tatjana Haitina
    Jaw joint regulatory sequence 1 (JRS1) is deeply conserved in most jawed vertebrates and displays a specific enhancer activity in the developing primary jaw joint that contributes to early nkx3.2 gene expression and jaw joint morphology.
    1. Immunology and Inflammation

    Cell-density independent increased lymphocyte production and loss rates post-autologous HSCT

    Mariona Baliu-Piqué, Vera van Hoeven ... Kiki Tesselaar
    Altered lymphocyte dynamics after hematopoietic stem cell transplantation cannot solely be explained by low lymphocyte numbers.
    1. Microbiology and Infectious Disease

    Longitudinal imaging of HIV-1 spread in humanized mice with parallel 3D immunofluorescence and electron tomography

    Collin Kieffer, Mark S Ladinsky ... Pamela J Bjorkman
    Combined tissue clearing, 3D-immunofluorescence, and electron tomography spatially revealed the dynamics of early HIV-1 spread within lymphoid tissues of humanized mice at the resolution of single cells and individual virions.

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