590 results found
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Non-crossover gene conversions show strong GC bias and unexpected clustering in humans

    Amy L Williams, Giulio Genovese ... Molly Przeworski
    In humans, non-crossover gene conversion events transmit GC alleles in 68% of cases and exhibit a complex pattern of multiple disconnected tracts clustered within 20–30 kilobase intervals.
    1. Ecology

    Genomic adaptations in information processing underpin trophic strategy in a whole-ecosystem nutrient enrichment experiment

    Jordan G Okie, Amisha T Poret-Peterson ... James J Elser
    Trait-based metagenomic analysis of an ecosystem fertilization experiment shows that genomic traits that affect the costs and rates of biochemical information-processing mediate community assembly.
    1. Epidemiology and Global Health
    2. Medicine

    Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19

    Nick K Jones, Lucy Rivett ... Michael P Weekes
    Diminished incidence of COVID-19 amongst healthcare workers in a comprehensive screening programme demonstrates how effective infection control measures and staff testing can prevent hospitals becoming independent 'hubs' of SARS-CoV-2 transmission.
    1. Chromosomes and Gene Expression

    GC content shapes mRNA storage and decay in human cells

    Maïté Courel, Yves Clément ... Dominique Weil
    The GC content of human mRNAs is key to P-body localization and protein yield, and has a major impact on their post-transcriptional control.
    1. Genetics and Genomics

    Recombination, meiotic expression and human codon usage

    Fanny Pouyet, Dominique Mouchiroud ... Marie Sémon
    Variation in codon usage among functional categories of human genes is not due to selection for translation efficiency, but to differences in intragenic recombination rate, linked to variation in meiotic transcription level.
    1. Evolutionary Biology
    2. Genetics and Genomics

    A paternal bias in germline mutation is widespread in amniotes and can arise independently of cell division numbers

    Marc de Manuel, Felix L Wu, Molly Przeworski
    A paternal bias in germline mutation is seen throughout amniotes and may be explained by sex differences in DNA damage and repair after primordial germ cell specification.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    The DNA-binding protein HTa from Thermoplasma acidophilum is an archaeal histone analog

    Antoine Hocher, Maria Rojec ... Tobias Warnecke
    In Thermoplasma acidophilum, an archaeon without histones, a DNA-binding protein acquired from bacteria via horizontal gene transfer mediates histone-like chromatin architecture.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Molecular rationale for antibody-mediated targeting of the hantavirus fusion glycoprotein

    Ilona Rissanen, Robert Stass ... Thomas A Bowden
    An integrated cryoEM and X-ray crystallography study resolves the structural basis for antibody-mediated targeting of the hantavirus fusion glycoprotein and provides insight into the conformational landscape of the hantavirion surface.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Circular RNA repertoires are associated with evolutionarily young transposable elements

    Franziska Gruhl, Peggy Janich ... David Gatfield
    Evolutionary analyses suggest that most mammalian circRNAs did not emerge from common ancestral circRNA precursors, arguing against widespread functional conservation.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Virophages and retrotransposons colonize the genomes of a heterotrophic flagellate

    Thomas Hackl, Sarah Duponchel ... Matthias G Fischer
    Mutualistic viruses called virophages are common genome inhabitants of a marine protist, where they may protect host populations from giant viruses.

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