The hypoxia-inducible factor HIF drives transcription of the gene cyp-36A1, which encodes a cytochrome P450 enzyme that acts via a putative intercellular signal to regulate the nuclear receptor NHR-46 and consequently stress resistance and behavior.

Neuroimaging shows brain responses to emotional pictures are more diminished in alcoholic men than in alcoholic women, implicating gender-related mechanisms of addiction.

Segment-specific boundaries of histone modifications reveal the regulatory logic of a classic developmental control region.

Comprehensive analyses of how mutations in a picornavirus capsid affect viral fitness provide novel insights into viral biology, evolution, and host interactions.

A technique called mSTARR-seq sheds light on how DNA methylation may shape responses to external stimuli by altering the activity of sequences that control gene expression.

A set of adaptive mutations affect only a small number of phenotypes that matter in the evolution condition, and yet contain substantial latent functional diversity revealed in distant environments.

CAMTA transcription factors are evolutionarily conserved regulators of neuronal levels of the major Ca²⁺ sensor calmodulin.

Single molecule DNA-binding trajectories and deterministic modeling analyses demonstrate a functional role for high energy partly folded states in Transcription Activator-Like Effectors that could improve future TALEN design.

Increasing cortical plasticity leads to better one-trial memory but more interference effects on semantic-like memory.

A behavioural paradigm demonstrates that during courtship song preference by female mice relies on the temporal regularity of the male's production of song syllables.