10,038 results found
    1. Evolutionary Biology
    2. Genetics and Genomics

    Gene flow mediates the role of sex chromosome meiotic drive during complex speciation

    Colin D Meiklejohn, Emily L Landeen ... Daven C Presgraves
    Selfish genetic elements may either promote or prevent the evolution of reproductive barriers, depending on the extent of gene flow between species.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Low-level repressive histone marks fine-tune gene transcription in neural stem cells

    Arjun Rajan, Lucas Anhezini ... Cheng-Yu Lee
    Stem-cell-specific transcriptional repressors fine-tune levels of stemness gene transcripts in asymmetrically dividing neural stem cells by depositing low levels of repressive histone marks at these loci allowing progeny to rapidly initiate differentiation.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Repeated origins, widespread gene flow, and allelic interactions of target-site herbicide resistance mutations

    Julia M Kreiner, George Sandler ... Stephen I Wright
    The spread of herbicide resistance in one of the most problematic weeds in North America occurs through both recent, repeated mutational origins and gene flow across an international network of agricultural fields.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The evolutionary history of human spindle genes includes back-and-forth gene flow with Neandertals

    Stéphane Peyrégne, Janet Kelso ... Svante Pääbo
    Analyses of spindle genes with missense changes in modern humans reveal evidence for positive selection since the split with archaic humans and show that modern humans interacted with Neandertals more than once in the past 200,000 years.
    1. Genetics and Genomics
    2. Evolutionary Biology

    Admixture into and within sub-Saharan Africa

    George BJ Busby, Gavin Band ... Malaria Genomic Epidemiology Network
    Gene flow analysis reveals that the genomes of most sub-Saharan populations are the result of recent historical admixture events.
    1. Immunology and Inflammation

    PTPN22 R620W gene editing in T cells enhances low-avidity TCR responses

    Warren Anderson, Fariba Barahmand-pour-Whitman ... David J Rawlings
    Gene editing to generate precisely matched primary human T cell populations demonstrates that the common autoimmune risk allele in the tyrosine phosphatase, PTPN22, promotes signaling in cells expressing a low-avidity, self-reactive TCR specific for a diabetes-associated self-antigen.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Admixture of evolutionary rates across a butterfly hybrid zone

    Tianzhu Xiong, Xueyan Li ... James Mallet
    Genetic barriers to gene flow maintain divergent linked substitution rates in hybridization.
    1. Cell Biology

    Alternative RNA splicing in the endothelium mediated in part by Rbfox2 regulates the arterial response to low flow

    Patrick A Murphy, Vincent L Butty ... Richard O Hynes
    Transcriptome analysis reveals an alternative splicing program induced in the arterial endothelium under low-flow inflammatory conditions by platelet and macrophage recruitment and dependent upon the RNA-binding splice factor Rbfox2.
    1. Neuroscience

    A low affinity cis-regulatory BMP response element restricts target gene activation to subsets of Drosophila neurons

    Anthony JE Berndt, Katerina M Othonos ... Douglas W Allan
    DNA motifs tuned for low affinity binding of BMP-induced pMad/Medea transcription factors function to restrict gene activation to small subsets of the many Drosophila neurons that exhibit active BMP signaling.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Intrinsic cooperativity potentiates parallel cis-regulatory evolution

    Trevor R Sorrells, Amanda N Johnson ... Alexander D Johnson
    Cooperativity between two transcription regulators occurs through protein-protein interactions with a general transcription factor complex and potentiates the parallel evolution of their DNA binding sites.

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