5,210 results found
    1. Neuroscience

    Brain aging comprises many modes of structural and functional change with distinct genetic and biophysical associations

    Stephen M Smith, Lloyd T Elliott ... Karla L Miller
    Imaging of structure and function in the brain from thousands of participants was used along with genetics and biophysical measures to study many different aspects of how the brain ages.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision

    James A Watson, Carolyne M Ndila ... Nicholas J White
    Complete blood count data can increase the accuracy of the diagnosis of severe malaria in children in high transmission settings.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Smoking, alcohol consumption, and 24 gastrointestinal diseases: Mendelian randomization analysis

    Shuai Yuan, Jie Chen ... Susanna C Larsson
    Smoking is a risk factor for a broad range of gastrointestinal diseases independent of alcohol consumption.
    1. Genetics and Genomics

    Limitations of principal components in quantitative genetic association models for human studies

    Yiqi Yao, Alejandro Ochoa
    It is always better to use mixed effects models over principal components association regression for genetic association studies of continuous traits, since the former models family structure and close relatives are always found in real human studies.
    1. Genetics and Genomics
    2. Medicine

    Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study

    Fernanda Morales Berstein, Daniel L McCartney ... Rebecca C Richmond
    GrimAge acceleration may increase the risk of colorectal cancer.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    A proteome-wide genetic investigation identifies several SARS-CoV-2-exploited host targets of clinical relevance

    Mohd Anisul, Jarrod Shilts ... Ian Dunham
    Genetic integration of human protein abundance variation and COVID-19 susceptibility identifies proteins with potential causal roles in antiviral responses, coagulation, cytokine activation, and direct receptor interactions with SARS-CoV-2.
    1. Genetics and Genomics

    Genetic insights into ossification of the posterior longitudinal ligament of the spine

    Yoshinao Koike, Masahiko Takahata ... Shiro Ikegawa
    A GWAS meta-analysis for OPLL identified fourteen significant genomic loci and a subsequent Mendelian randomization study provided genetic evidence for a causal effect of obesity on the pathogenesis of OPLL, especially one of its subtypes, thoracic OPLL.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Integrated analyses of growth differentiation factor-15 concentration and cardiometabolic diseases in humans

    Susanna Lemmelä, Eleanor M Wigmore ... Athena Matakidou
    Elevated growth differentiation factor-15 (GDF15) levels do not appear to be a causal factor in body mass index (BMI) in humans but higher BMI does cause increases in GDF15.
    1. Genetics and Genomics

    Passive and active DNA methylation and the interplay with genetic variation in gene regulation

    Maria Gutierrez-Arcelus, Tuuli Lappalainen ... Emmanouil T Dermitzakis
    Detailed analysis of umbilical cord cells shows that the associations between DNA methylation, gene expression and genetic variation are complex and context-dependent.
    1. Genetics and Genomics

    The missing link between genetic association and regulatory function

    Noah J Connally, Sumaiya Nazeen ... Shamil R Sunyaev
    A common conceptual model exists in which trait-associated genetic variants that do not alter protein structure act by changing gene expression, but, in the context in which expression is often measured, this model is inconsistent with observed data.

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