A systematic genetic analysis comprising seven genome-wide screens in haploid human cells uncovered new regulatory mechanisms at most levels in the WNT signaling pathway.

A mechanosensitive ion channel physically and genetically interacts with proteins that function at endoplasmic reticulum–plasma membrane contact sites.

Med16 and GSK3b regulate interferon gamma-mediated MHCII expression in macrophages and are required for CD4+ T cell activation.

An RNAi screen in mouse hippocampal neuronal cell line targeting epigenetic regulators revealed a novel neuroprotection of Prmt5 and uncovered its nucleus translocation feature and epigenetic mechanism in cerebral ischemia.

A whole-genome genetic screen links new aspects of oocyte maturation to proteostasis renewal in the immortal Caenorhabditis elegans germ-cell lineage and reveals similarities to somatic cell maintenance during aging.

Computational approach to identify reproducible genetic interactions in cancer reveals that they are enriched among protein–protein interaction pairs.

Mutations conferring resistance to Escherichia coli against the chemotherapy drug gemcitabine can have opposite effects on bacterial drug degradation and therefore can increase or decrease the chemotherapy load on neighboring cancer cells.

A CRISPR-based method enables targeted knockouts and genetic screens in human dendritic cells.

Five previously unknown alternative genetic codes are found in a screen of bacterial and archaeal genomes by a new computational method called Codetta, lending new insights into the process of their evolution.

The ubiquitous second messenger cyclic AMP, produced by Rv3645/MacE, controls long-chain fatty acid metabolism and intrinsic multidrug resistance in M. tuberculosis.