The ubiquitous second messenger cyclic AMP, produced by Rv3645/MacE, controls long-chain fatty acid metabolism and intrinsic multidrug resistance in M. tuberculosis.
A systematic genetic analysis comprising seven genome-wide screens in haploid human cells uncovered new regulatory mechanisms at most levels in the WNT signaling pathway.
Changyu Zhu, Yadira M Soto-Feliciano ... Scott W Lowe
Epigenetic regulator MLL3 is mutated and lost in human hepatocellular carcinoma due to its ability to activate a well-defined tumor suppressor and cell death in transformed cells.
Marian Chuang, Tiffany I Hsiao ... Andrew D Chisholm
Genetic suppressor screens with C. elegans reveal a novel function for the Death Associated Protein Kinase in regulation of epithelial microtubule dynamics.
Ryan C Vignogna, Mariateresa Allocca ... Gregory I Lang
Experimental evolution of yeast models of congenital disorders of glycosylation reveals that reduction, but not loss, of phosphoglucomutase activity best compensates for impaired phosphomannomutase activity.