6,480 results found
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Niche-specific genome degradation and convergent evolution shaping Staphylococcus aureus adaptation during severe infections

    Stefano G Giulieri, Romain Guérillot ... Benjamin P Howden
    A large-scale analysis of Staphylococcus aureus within-host evolution based on a comprehensive catalogue of bacterial genetic variation reveals an excess of genome degradation signatures in infecting strains and new genetic loci of clinically relevant adaptation.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Little skate genome provides insights into genetic programs essential for limb-based locomotion

    DongAhn Yoo, Junhee Park ... Myungin Baek
    The generation of high-quality little skate reference genome enables molecular mechanism studies of gene regulation.
    1. Chromosomes and Gene Expression

    Super-resolution imaging of a 2.5 kb non-repetitive DNA in situ in the nuclear genome using molecular beacon probes

    Yanxiang Ni, Bo Cao ... Hanben Niu
    Molecular beacon based FISH shows the capability of visualizing a 2.5 kb non-repetitive genomic DNA sequence in situ in human or mouse nuclear genome at super resolution.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    An evolutionary model identifies the main evolutionary biases for the evolution of genome-replication profiles

    Rossana Droghetti, Nicolas Agier ... Marco Cosentino Lagomarsino
    Mathematical modeling and data analysis show that, over evolutionary times, the yeast temporal program of replication strives to avoid stalling events and minimize interference between neighbor origins.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Evolution of binding preferences among whole-genome duplicated transcription factors

    Tamar Gera, Felix Jonas ... Naama Barkai
    The fate of duplicated transcription factors within budding yeast is described, providing insights into the mechanisms that shape transcriptional networks during evolution.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The whale shark genome reveals patterns of vertebrate gene family evolution

    Milton Tan, Anthony K Redmond ... Timothy Read
    The new whale shark genome assembly represents the best gapless chondrichthyan genome assembly yet, and comparative genomic analyses provide insights into the evolution of vertebrate genome origins, immunity, and gigantism.
    1. Chromosomes and Gene Expression

    A simple method for generating high-resolution maps of genome-wide protein binding

    Peter J Skene, Steven Henikoff
    Building on previous work (Skene et al., 2014), we show that a new ChIP-seq protocol provides superior resolution and ease of use at low sequence depth of coverage for generating genome-wide maps of protein binding.
    1. Evolutionary Biology

    Species-specific chromatin landscape determines how transposable elements shape genome evolution

    Yuheng Huang, Harsh Shukla, Yuh Chwen G Lee
    The ultimate driver for the substantial between-species difference in the success of transposable elements, the widely distributed genetic parasite, may lie in the overall chromatin environment.
    1. Chromosomes and Gene Expression

    High-resolution, genome-wide mapping of positive supercoiling in chromosomes

    Monica S Guo, Ryo Kawamura ... Michael T Laub
    GapR-seq enables the global mapping of positive supercoiling in bacteria and yeast, revealing positive supercoils downstream of highly expressed genes and, in yeast, associated with centromeres, pericentromeres, telomeres, replication origins, and R-loops.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Evidence for a common evolutionary rate in metazoan transcriptional networks

    Anne-Ruxandra Carvunis, Tina Wang ... Trey Ideker
    Transcriptional regulation evolves at indistinguishable rates in mammals, birds and insect lineages despite large differences in underlying rates of sequence evolution.
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