Sarah E Zanders, Michael T Eickbush ... Harmit Singh Malik
Rapid acquisition of chromosome rearrangements, together with independently acting transmission distorter alleles on each chromosome, drive near complete sterility in fission yeast hybrids.
Complex chromosomal rearrangements similar to those described in cancer and developmental syndromes occur in plants during postzygotic genome elimination, a centromeric-derived incompatibility.
Bin-zhong Li, Christopher D Putnam, Richard David Kolodner
Genetic analysis combined with whole genome sequencing elucidates mechanisms and pathways that form and prevent a specific class of genome rearrangements, foldback inversions, seen in many human cancers.
Eileen P Hamilton, Aurélie Kapusta ... Robert S Coyne
The model organism Tetrahymena thermopile carries two nuclei with distinct genomes: an unrearranged germline genome with five chromosomes, and a somatic genome reduced in size by a third and with 181 chromosomes.
The comparison of three ciliate species that share complex pathways for natural genome editing allows capture of intermediate states in the acquisition of scrambled genes and elucidating a pathway for the origin and evolution of extremely rearranged chromosomes.
Previously uncharacterized long repeat sequences are associated with significant genome variation that can increase fitness and promote antifungal drug resistance in diverse isolates of Candida albicans.