Patricia Giselle Cipriani, Olivia Bay ... Kristin C Gunsalus
Two novel LOTUS-domain proteins are core germ granule components that directly recruit Caenorhabditis elegans Vasa, regulate germ granule size and localization, and provide an organizational framework for ribonucleoprotein complexes.
A proximity labeling approach defines germ granule proteome in Caenorhabditis elegans, and identifies LOTUS domain proteins as key regulators of germ granule assembly.
The scaffolding protein Oskar organizes two types of germ granules by phase transition within the same cell but with distinct morphologies, composition and biological functions.
Catherine E Eichler, Anna C Hakes ... Elizabeth R Gavis
RNP granules confer temporal and spatial regulation of oskar mRNA degradation to minimize inheritance of oskar mRNAby germ cells and thereby protect germline development.
Merrick D Pierson Smela, Christian C Kramme ... George M Church
Making human stem cells express certain transcription factors can convert them into cells that are similar to ovarian granulosa cells, and perform several important functions of the ovary.
Kevin I Manage, Alicia K Rogers ... Carolyn Marie Phillips
SIMR-1 acts downstream of the piRNA pathway to promote siRNA amplification by the Mutator complex and localizes to perinuclear foci distinct from Mutator foci, P granules and Z granules.