166 results found
    1. Cell Biology
    2. Developmental Biology

    Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules

    Patricia Giselle Cipriani, Olivia Bay ... Kristin C Gunsalus
    Two novel LOTUS-domain proteins are core germ granule components that directly recruit Caenorhabditis elegans Vasa, regulate germ granule size and localization, and provide an organizational framework for ribonucleoprotein complexes.
    1. Cell Biology

    Proximity labeling identifies LOTUS domain proteins that promote the formation of perinuclear germ granules in C. elegans

    Ian F Price, Hannah L Hertz ... Wen Tang
    A proximity labeling approach defines germ granule proteome in Caenorhabditis elegans, and identifies LOTUS domain proteins as key regulators of germ granule assembly.
    1. Cell Biology
    2. Developmental Biology

    Recruitment of mRNAs to P granules by condensation with intrinsically-disordered proteins

    Chih-Yung S Lee, Andrea Putnam ... Geraldine Seydoux
    The intrinsically-disordered protein MEG-3 recruits mRNAs to P granules by forming gel-like condensates with ribosome-depleted mRNAs.
    1. Cell Biology

    Phase transitioned nuclear Oskar promotes cell division of Drosophila primordial germ cells

    Kathryn E Kistler, Tatjana Trcek ... Ruth Lehmann
    The scaffolding protein Oskar organizes two types of germ granules by phase transition within the same cell but with distinct morphologies, composition and biological functions.
    1. Cell Biology
    2. Developmental Biology

    Regulation of RNA granule dynamics by phosphorylation of serine-rich, intrinsically disordered proteins in C. elegans

    Jennifer T Wang, Jarrett Smith ... Geraldine Seydoux
    The MEG (maternal-effect germline defective) proteins, MEG-1, 2, 3 and 4, regulate RNA granule dynamics in vivo.
    1. Developmental Biology

    Compartmentalized oskar degradation in the germ plasm safeguards germline development

    Catherine E Eichler, Anna C Hakes ... Elizabeth R Gavis
    RNP granules confer temporal and spatial regulation of oskar mRNA degradation to minimize inheritance of oskar mRNAby germ cells and thereby protect germline development.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Directed differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression

    Merrick D Pierson Smela, Christian C Kramme ... George M Church
    Making human stem cells express certain transcription factors can convert them into cells that are similar to ovarian granulosa cells, and perform several important functions of the ovary.
    1. Chromosomes and Gene Expression

    A tudor domain protein, SIMR-1, promotes siRNA production at piRNA-targeted mRNAs in C. elegans

    Kevin I Manage, Alicia K Rogers ... Carolyn Marie Phillips
    SIMR-1 acts downstream of the piRNA pathway to promote siRNA amplification by the Mutator complex and localizes to perinuclear foci distinct from Mutator foci, P granules and Z granules.
    1. Cell Biology
    2. Developmental Biology

    Spatial patterning of P granules by RNA-induced phase separation of the intrinsically-disordered protein MEG-3

    Jarrett Smith, Deepika Calidas ... Geraldine Seydoux
    A competition for RNA drives the localized assembly of RNA granules in the C. elegans embryo.
    1. Cell Biology
    2. Developmental Biology

    Germ Granules: All about the RNA after all

    Tatjana Trcek, Ruth Lehmann
    RNA molecules cause the proteins involved in the formation of germ granules to coalesce into liquid droplets.
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