1,953 results found
    1. Cell Biology
    2. Developmental Biology

    Nanos promotes epigenetic reprograming of the germline by down-regulation of the THAP transcription factor LIN-15B

    Chih-Yung Sean Lee, Tu Lu, Geraldine Seydoux
    Nanos is required for germline specification by erasure of maternal program in primordial germ cells.
    1. Cell Biology
    2. Developmental Biology

    Spatial patterning of P granules by RNA-induced phase separation of the intrinsically-disordered protein MEG-3

    Jarrett Smith, Deepika Calidas ... Geraldine Seydoux
    A competition for RNA drives the localized assembly of RNA granules in the C. elegans embryo.
    1. Developmental Biology

    Maternal H3K36 and H3K27 HMTs protect germline development via regulation of the transcription factor LIN-15B

    Chad Steven Cockrum, Susan Strome
    The H3K36 and H3K27 histone methyltransferases MES-4 and PRC2 protect survival of the nascent germline in Caenorhabditis elegans by repressing expression of X-linked genes, including the key transcription factor LIN-15B.
    1. Cell Biology
    2. Developmental Biology

    Regulation of RNA granule dynamics by phosphorylation of serine-rich, intrinsically disordered proteins in C. elegans

    Jennifer T Wang, Jarrett Smith ... Geraldine Seydoux
    The MEG (maternal-effect germline defective) proteins, MEG-1, 2, 3 and 4, regulate RNA granule dynamics in vivo.
    1. Developmental Biology

    Neuronal octopamine signaling regulates mating-induced germline stem cell increase in female Drosophila melanogaster

    Yuto Yoshinari, Tomotsune Ameku ... Ryusuke Niwa
    Genetic analyses using the fruit fly illustrate how neuronal system couples germline stem cell increase to an external cue, which is mating, through stem cell niche signaling.
    1. Cell Biology
    2. Developmental Biology

    Recruitment of mRNAs to P granules by condensation with intrinsically-disordered proteins

    Chih-Yung S Lee, Andrea Putnam ... Geraldine Seydoux
    The intrinsically-disordered protein MEG-3 recruits mRNAs to P granules by forming gel-like condensates with ribosome-depleted mRNAs.
    1. Immunology and Inflammation

    Gut Helicobacter presentation by multiple dendritic cell subsets enables context-specific regulatory T cell generation

    Emilie V Russler-Germain, Jaeu Yi ... Chyi-Song Hsieh
    In vitro and in vivo studies show that multiple dendritic cell subsets are capable of presenting gut Helicobacter antigens to induce regulatory T cells.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    IFN-mediated negative feedback supports bacteria class-specific macrophage inflammatory responses

    Rachel A Gottschalk, Michael G Dorrington ... Ronald N Germain
    Inflammatory dynamics are tailored to bacterial class through macrophage integration of microbial stimuli and cytokine feedback.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    SET-9 and SET-26 are H3K4me3 readers and play critical roles in germline development and longevity

    Wenke Wang, Amaresh Chaturbedi ... Siu Sylvia Lee
    Two SET-domain containing proteins regulate H3K4me3 by their binding to H3K4me3 through their PHD domain and directly regulate expression of a subset of genes.
    1. Cell Biology
    2. Developmental Biology

    Endogenous siRNAs promote proteostasis and longevity in germline-less Caenorhabditis elegans

    Moran Cohen-Berkman, Reut Dudkevich ... Sivan Henis-Korenblit
    Endo-siRNAs slow down the rate of aging and enable the maintenance of a responsive heat shock response in aging germline-less Caenorhabditis elegans.

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