616 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Glypican-1 drives unconventional secretion of fibroblast growth factor 2

    Carola Sparn, Eleni Dimou ... Walter Nickel
    Identification of a heparan sulfate proteoglycan with a dedicated function in unconventional protein secretion reveals an intimate relationship between fibroblast growth factor 2 and Glypican-1 in cancer biology.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Ligand modulation of sidechain dynamics in a wild-type human GPCR

    Lindsay D Clark, Igor Dikiy ... Daniel M Rosenbaum
    Generation of a highly deuterated 13C-methyl labeled wild-type GPCR sample is used to facilitate characterization of the molecular environments and fast ps-ns dynamics of sidechains when the receptor is bound to ligands of different efficacy.
    1. Neuroscience

    Cortical astrocytes independently regulate sleep depth and duration via separate GPCR pathways

    Trisha V Vaidyanathan, Max Collard ... Kira E Poskanzer
    Cortical astrocytes play key roles in NREM sleep by regulating sleep depth and duration through separate GPCR pathways, and differentially control neuronal slow-wave activity in local and remote cortical circuits.
    1. Cell Biology
    2. Developmental Biology

    The cAMP effector PKA mediates Moody GPCR signaling in Drosophila blood–brain barrier formation and maturation

    Xiaoling Li, Richard Fetter ... Ulrike Gaul
    A polarized Moody/protein kinase A pathway plays an unrecognized central role in controlling the enormous cell growth and blood–brain barrier integrity in a highly coordinated spatiotemporal manner in brain homeostasis.
    1. Computational and Systems Biology

    Common coupling map advances GPCR-G protein selectivity

    Alexander S Hauser, Charlotte Avet ... David E Gloriam
    The GPCR-G protein coupling map and selectivity insights will catalyze advances in receptor research, cellular signaling, and drug discovery exploiting G protein signaling bias to design safer drugs.
    1. Cancer Biology

    GPC1 specific CAR-T cells eradicate established solid tumor without adverse effects and synergize with anti-PD-1 Ab

    Daiki Kato, Tomonori Yaguchi ... Yutaka Kawakami
    The safety and strong antitumor effects of GPC1-specific CAR-T cells against GPC1-expressing solid tumors were demonstrated by using both syngeneic and xenogeneic mouse models.
    1. Cell Biology
    2. Developmental Biology

    R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling

    Ramin Dubey, Peter van Kerkhof ... Rajat Rohatgi
    Heparan Sulfate Proteoglycans function as receptors for the R-spondins, a family of growth factors that amplify the strength of WNT signaling during development and in adult stem cells.
    1. Cell Biology

    Discrete GPCR-triggered endocytic modes enable β-arrestins to flexibly regulate cell signaling

    Benjamin Barsi-Rhyne, Aashish Manglik, Mark von Zastrow
    Two modes of GPCR endocytosis by β-arrestin are differentially coupled to downstream signaling.
    1. Neuroscience

    Antinociceptive modulation by the adhesion GPCR CIRL promotes mechanosensory signal discrimination

    Sven Dannhäuser, Thomas J Lux ... Robert J Kittel
    An interdisciplinary approach uncovers a new antinociceptive molecular mechanism and shows that the adhesion GPCR CIRL adjusts the sensation of gentle touch and noxious mechanical insult in opposite directions.
    1. Cell Biology

    Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered agonist-mediated activation mechanism

    James P Bridges, Caterina Safina ... Marie-Gabrielle Ludwig
    Mutagenesis and activity assays in vitro and in vivo identify residues in the tethered agonist of GPR116, as well as those within the extracellular loops, that are critical for mediating the response to the tethered agonist.

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