2,368 results found
    1. Structural Biology and Molecular Biophysics

    Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2

    Dari Kimanius, Björn O Forsberg ... Erik Lindahl
    Using GPUs for the costly computations in cryo-EM enables structure determination in mere days on a single workstation.
    1. Neuroscience

    Globus pallidus dynamics reveal covert strategies for behavioral inhibition

    Bon-Mi Gu, Robert Schmidt, Joshua D Berke
    Rats can pre-position the state of their basal ganglia neural networks to adaptively influence their subsequent response to a Go signal.
    1. Evolutionary Biology

    Ovipositor and mouthparts in a fossil insect support a novel ecological role for early orthopterans in 300 million years old forests

    Lu Chen, Jun-Jie Gu ... Olivier Béthoux
    Hundreds of fossil remains shed new light on the evolution of grasshoppers, gryllids, and katydids and their ecological role 300 million years ago.
    1. Stem Cells and Regenerative Medicine

    AIRE is a critical spindle-associated protein in embryonic stem cells

    Bin Gu, Jean-Philippe Lambert ... Janet Rossant
    AIRE played novel roles in the mitosis process in embryonic stem cells and early embryo cells.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses

    Simon Langer, Christian Hammer ... Daniel Sauter
    By inhibiting the activation of NF-κB, HIV-1 Vpu exerts much broader immunosuppressive effects than previously anticipated and may be an important determinant of chronic inflammation in HIV-1 infected individuals.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1

    Xiaofei Jia, Erin Weber ... Yong Xiong
    HIV-1 viral protein u (Vpu) can stimulate novel versions of canonical interactions with the clathrin adaptor AP1 to counteract the host antiviral protein BST2.
    1. Neuroscience

    Robust vestibular self-motion signals in macaque posterior cingulate region

    Bingyu Liu, Qingyang Tian, Yong Gu
    Macaque posterior cingulate region carries vestibular dominant self-motion signals with plentiful temporal components that could be useful for process of path integration.
    1. Neuroscience

    Imaging microglia surveillance during sleep-wake cycles in freely behaving mice

    Xiaochun Gu, Zhong Zhao ... Heping Cheng
    Using long-term in vivo imaging with miniature two-photon microscopy, microglia surveillance is sleep state-dependent and stress-induced in freely behaving mice, regulated by the locus coeruleus-norepinephrine system and β2-adrenergic receptors signaling.
    1. Chromosomes and Gene Expression

    Caenorhabditis elegans nuclear RNAi factor SET-32 deposits the transgenerational histone modification, H3K23me3

    Lianna Schwartz-Orbach, Chenzhen Zhang ... Sam G Gu
    H3K23me3 is a RNAi-mediated transgenerationally heritable heterochromatin mark in Caenorhabditis elegans.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Mapping cell type-specific transcriptional enhancers using high affinity, lineage-specific Ep300 bioChIP-seq

    Pingzhu Zhou, Fei Gu ... William T Pu
    A method for measuring p300 chromatin occupancy in specific lineages of mouse tissues was used to map endothelial enhancers and to identify previously unrecognized angiogenesis-related sequence motifs.

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