686 results found
    1. Neuroscience

    Synaptic representation of locomotion in single cerebellar granule cells

    Kate Powell, Alexandre Mathy ... Michael Häusser
    The first patch-clamp recordings from single cerebellar granule cells during locomotion reveal that the entire step sequence can be predicted from both excitatory synaptic input and output spikes from a single neuron.
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    1. Developmental Biology
    2. Neuroscience

    p75NTR prevents the onset of cerebellar granule cell migration via RhoA activation

    Juan P Zanin, Wilma J Friedman
    The p75 neurotrophin receptor prevents the migration of the granule cell precursors away from its mitogenic niche in the external granule layer of the cerebellum, by maintaining a pool of undifferentiated cells capable of responding to mitogenic signals.
    1. Computational and Systems Biology
    2. Neuroscience

    Adult-born granule cells improve stimulus encoding and discrimination in the dentate gyrus

    Diego M Arribas, Antonia Marin-Burgin, Luis G Morelli
    Heterogeneity in the population of granule cells in the dentate gyrus, which includes immature and mature neurons with distinct intrinsic properties, contributes to the population's enhanced encoding capabilities and ability to discriminate correlated stimuli.
    1. Cell Biology
    2. Neuroscience

    KIF2A regulates the development of dentate granule cells and postnatal hippocampal wiring

    Noriko Homma, Ruyun Zhou ... Nobutaka Hirokawa
    Postnatal KIF2A is a key regulator for axon/dendrite determination of developing dentate granule cells, and its loss developed apical axons in dentate molecular layer, broke hippocampal wiring, and induced temporal lobe epilepsy.
    1. Cell Biology
    2. Neuroscience

    Proneurotrophin-3 promotes cell cycle withdrawal of developing cerebellar granule cell progenitors via the p75 neurotrophin receptor

    Juan Pablo Zanin, Elizabeth Abercrombie, Wilma J Friedman
    The p75 neurotrophin receptor regulates when granule neuron progenitors exit the cell cycle in the developing cerebellum.
    1. Neuroscience

    Multimodal sensory integration in single cerebellar granule cells in vivo

    Taro Ishikawa, Misa Shimuta, Michael Häusser
    Building on previous work (Huang et al., 2013), it is shown that single granule cells receive excitatory synaptic input driven by up to three separate sensory modalities in vivo, which demonstrate that individual neurons can contribute to multisensory integration at the input layer of the cerebellar cortex.
    1. Neuroscience

    Convergence of pontine and proprioceptive streams onto multimodal cerebellar granule cells

    Cheng-Chiu Huang, Ken Sugino ... Adam W Hantman
    Individual granule cells within the cerebellum-the region of the brain that coordinates movement and supports the learning of new motor skills-receive both sensory and motor input streams: an arrangement that may help the brain to use feedback to fine-tune movement.
    1. Neuroscience

    Presynaptic NMDARs cooperate with local spikes toward GABA release from the reciprocal olfactory bulb granule cell spine

    Vanessa Lage-Rupprecht, Li Zhou ... Veronica Egger
    The essential role of presynaptic NMDA receptors for granule cell GABAergic output elucidates the function of reciprocal spines in recurrent and possibly lateral inhibition of mitral cells during olfactory processsing.
    1. Neuroscience

    All-trans retinoic acid induces synaptopodin-dependent metaplasticity in mouse dentate granule cells

    Maximilian Lenz, Amelie Eichler ... Andreas Vlachos
    All-trans retinoic acid increases the number of excitatory synapses in the dorsal hippocampus of mice and improves the ability of neurons to express synaptopodin-dependent synaptic plasticity.
    1. Neuroscience

    Sparse activity of identified dentate granule cells during spatial exploration

    Maria Diamantaki, Markus Frey ... Andrea Burgalossi
    Morphologically-mature granule cells with complex dendritic trees contribute to a sparse representation of space in the rat dentate gyrus.
    Short Report Updated
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