7,010 results found
    1. Computational and Systems Biology
    2. Neuroscience

    Shared and modality-specific brain regions that mediate auditory and visual word comprehension

    Anne Keitel, Joachim Gross, Christoph Kayser
    The comprehension of acoustic and visual speech depends on modality-specific pathways in the brain, which explains why auditory speech abilities and lip reading are not associated in typical adults.
    1. Genetics and Genomics

    Integration of genomics and transcriptomics predicts diabetic retinopathy susceptibility genes

    Andrew D Skol, Segun C Jung ... Michael A Grassi
    Integrating gene expression with genetic association data provided insights into the functional relevance of genetic risk for a complex disease, thus implicating folliculin as a putative diabetic retinopathy susceptibility gene.
    1. Chromosomes and Gene Expression

    Tissue damage drives co-localization of NF-κB, Smad3, and Nrf2 to direct Rev-erb sensitive wound repair in mouse macrophages

    Dawn Z Eichenfield, Ty Dale Troutman ... Christopher K Glass
    Combinatorial signaling leads to transcription factor co-localization at Rev-erb sensitive enhancers, enabling a diversified cellular response to complex stimuli.
    1. Neuroscience

    Dynamic encoding of social threat and spatial context in the hypothalamus

    Piotr Krzywkowski, Beatrice Penna, Cornelius T Gross
    Threat and context-responsive neurons in the ventromedial hypothalamus are reshaped by experience to drive social avoidance.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Systematic analysis of naturally occurring insertions and deletions that alter transcription factor spacing identifies tolerant and sensitive transcription factor pairs

    Zeyang Shen, Rick Z Li ... Christopher K Glass
    Collaborative transcription factors (TFs) exhibit a dominant pattern of a relaxed range of spacing and substantial tolerance of spacing alterations resulting from naturally occurring insertions and deletions in comparison to genetic variants directly affecting TF binding sites.
    1. Neuroscience

    Coupling of pupil- and neuronal population dynamics reveals diverse influences of arousal on cortical processing

    Thomas Pfeffer, Christian Keitel ... Joachim Gross
    Spontaneous fluctuations in pupil-indexed arousal shape human cortical dynamics in a frequency-dependent and spatially diverse manner.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Operon mRNAs are organized into ORF-centric structures that predict translation efficiency

    David H Burkhardt, Silvi Rouskin ... Carol A Gross
    Operonic mRNAs in bacteria are comprised of ORF (open reading frame)-wide units of secondary structure, which are intrinsically distinct between adjacent ORFs and encode a rough blueprint for ORF-specific translation efficiency.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells

    Karmel A Allison, Eniko Sajti ... Christopher K Glass
    Pre-existing enhancers interpret T cell signaling strength in an analogue manner to direct quantitative changes in gene expression within the context of an overall digital response.
    1. Immunology and Inflammation

    Defining murine monocyte differentiation into colonic and ileal macrophages

    Mor Gross-Vered, Sébastien Trzebanski ... Steffen Jung
    Detailed analysis of the sequence of monocyte differentiation into distinct gut tissue macrophages provides insights into monocyte biology and can serve as a platform for the design of cell therapies.
    1. Neuroscience

    Respiration aligns perception with neural excitability

    Daniel S Kluger, Elio Balestrieri ... Joachim Gross
    Noninvasive human magnetoencephalography recordings characterize the functional relationship between respiration, neural oscillations, and performance in low-level perception.

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