10,671 results found
    1. Structural Biology and Molecular Biophysics

    On the importance of statistics in molecular simulations for thermodynamics, kinetics and simulation box size

    Vytautas Gapsys, Bert L de Groot
    The use of adequate statistics is demonstrated to be an essential prerequisite to derive conclusions on thermodynamics and kinetics from molecular simulations.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Tiled-ClickSeq for targeted sequencing of complete coronavirus genomes with simultaneous capture of RNA recombination and minority variants

    Elizabeth Jaworski, Rose M Langsjoen ... Andrew L Routh
    Tiled-ClickSeq provides a simple and novel next-generation sequencing approach for complete genome sequencing of viruses including SARS-CoV-2, whilst capturing RNA recombination events and minority variants.
    1. Microbiology and Infectious Disease

    Single cell preparations of Mycobacterium tuberculosis damage the mycobacterial envelope and disrupt macrophage interactions

    Ekansh Mittal, Andrew T Roth ... Jennifer A Philips
    The experimental methods that are routinely used to disperse mycobacterial aggregates markedly impact macrophage infection outcomes, which should be taken into account to appropriately interpret host-pathogen interactions studies.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Modeling the metabolic interplay between a parasitic worm and its bacterial endosymbiont allows the identification of novel drug targets

    David M Curran, Alexandra Grote ... John Parkinson
    A genome scale model of Brugia malayi metabolism illustrates a dynamic reliance on energy production pathways across its life cycle and identifies new drugs with experimentally supported anti-parasitic properties.
    1. Developmental Biology

    A novel role for Ets4 in axis specification and cell migration in the spider Parasteatoda tepidariorum

    Matthias Pechmann, Matthew A Benton ... Siegfried Roth
    In the spider Parasteatoda tepidariorum the transcription factor Ets4 is needed for cumulus integrity, dorsoventral patterning and for the activation of hunchback and twist expression.
    1. Epidemiology and Global Health

    Telomere length is associated with growth in children in rural Bangladesh

    Audrie Lin, Andrew N Mertens ... John M Colford Jr
    In a rural, low-income setting in Bangladesh, early-life telomere length was associated with concurrent growth.
    1. Microbiology and Infectious Disease

    Interactions between metabolism and growth can determine the co-existence of Staphylococcus aureus and Pseudomonas aeruginosa

    Camryn Pajon, Marla C Fortoul ... Robert P Smith
    The growth environment driven ratio of ATP to growth rate, called absolute growth, determines the final population composition of Staphylococcus aureus and Pseudomonas aeruginosa when in co-culture.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Distinguishing different modes of growth using single-cell data

    Prathitha Kar, Sriram Tiruvadi-Krishnan ... Ariel Amir
    Single-cell data analysis must be guided by an underlying model.
    1. Neuroscience

    Synchronized excitability in a network enables generation of internal neuronal sequences

    Yingxue Wang, Zachary Roth, Eva Pastalkova
    Hippocampal sharp-wave sequences, which are considered the key phenomenon underlying consolidation of episodic memory, are preserved even after an animal’s memory is impaired.
    1. Cell Biology
    2. Physics of Living Systems

    Volume growth in animal cells is cell cycle dependent and shows additive fluctuations

    Clotilde Cadart, Larisa Venkova ... Marco Cosentino Lagomarsino
    High-throughput measurement of single-cell volume reveals the short and large timescale fluctuation patterns of animal cell volume growth.

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