7,287 results found
    1. Developmental Biology
    2. Plant Biology

    The Arabidopsis transcription factor ABIG1 relays ABA signaled growth inhibition and drought induced senescence

    Tie Liu, Adam D Longhurst ... M Kathryn Barton
    Arabidopsis plants slow growth and jettison leaves in response to drought via a mechanism that involves the transcription factor ABIG1.
    1. Neuroscience

    Circulating transforming growth factor-β1 facilitates remyelination in the adult central nervous system

    Machika Hamaguchi, Rieko Muramatsu ... Toshihide Yamashita
    Although central nervous system (CNS) regeneration has been considered to be controlled by CNS microenvironment, CNS injury causes leading to leakage of circulating factors into CNS, which promotes CNS regeneration.
    1. Developmental Biology

    Dephosphorylation of the NPR2 guanylyl cyclase contributes to inhibition of bone growth by fibroblast growth factor

    Leia C Shuhaibar, Jerid W Robinson ... Laurinda A Jaffe
    Fibroblast growth factor induces dephosphorylation and inactivation of the NPR2 guanylyl cyclase, thus decreasing cyclic GMP production in growth plate chondrocytes and contributing to FGF-dependent decreases in bone growth.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor

    Yongjian Huang, Jana Ognjenovic ... John Kuriyan
    Cryo-EM analysis of full-length human epidermal growth factor receptor provides a molecular explanation for how ligand-induced differential effect in the ligand-binding extracellular module tunes the transmembrane signaling mediated by epidermal growth factor receptor.
    1. Cell Biology
    2. Developmental Biology

    The NDNF-like factor Nord is a Hedgehog-induced extracellular BMP modulator that regulates Drosophila wing patterning and growth

    Shu Yang, Xuefeng Wu ... Xiaoyan Zheng
    The NDNF-like factor Nord is a Hedgehog-induced and extracellular-localized dosage-dependent BMP modulator that regulates Drosophila wing patterning and growth.
    1. Developmental Biology

    Growth-factor-mediated coupling between lineage size and cell fate choice underlies robustness of mammalian development

    Néstor Saiz, Laura Mora-Bitria ... Anna-Katerina Hadjantonakis
    A mechanistic basis is provided for the regulative ability of the mammalian embryo offering a long-sought explanation for coordinating cell behaviors at the population level ensuring robustness in developmental outcome.
    1. Cell Biology

    Epidermal Growth Factor Receptor neddylation is regulated by a desmosomal-COP9 (Constitutive Photomorphogenesis 9) signalosome complex

    Nicole Ann Najor, Gillian Nicole Fitz ... Kathleen Janee Green
    A protein interaction screen revealed desmosomes as a scaffold for the COP9 de-neddylating complex, to promote epidermal differentiation by governing the balance of Nedd8 and Ubiquitin modifications on Epidermal Growth Factor Receptor.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling

    Adam Graham Grieve, Hongmei Xu ... Matthew Freeman
    The iRhom2 protein, a catalytically inactive relative of rhomboid proteases, controls inflammation and growth factor signalling by acting as an essential multifunctional regulatory subunit of the cell surface shedding protease TACE (ADAM17).
    1. Cell Biology

    Regulation of EGFR signal transduction by analogue-to-digital conversion in endosomes

    Roberto Villaseñor, Hidenori Nonaka ... Marino Zerial
    Cells package active receptors in endosomes at fairly constant amounts and can determine different cell-fate decisions by regulating the number and lifetime of receptor packages.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Glypican-1 drives unconventional secretion of fibroblast growth factor 2

    Carola Sparn, Eleni Dimou ... Walter Nickel
    Identification of a heparan sulfate proteoglycan with a dedicated function in unconventional protein secretion reveals an intimate relationship between fibroblast growth factor 2 and Glypican-1 in cancer biology.

Refine your results by:

Type
Research categories