24 results found
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Target binding triggers hierarchical phosphorylation of human Argonaute-2 to promote target release

    Brianna Bibel, Elad Elkayam ... Leemor Joshua-Tor
    The central RNA interference protein, human Argonaute-2, releases its target following phosphorylation on a critical loop in the protein, freeing microRNA-bound Argonaute-2 to seek out and repress additional targets.
    1. Developmental Biology

    CED-3 caspase acts with miRNAs to regulate non-apoptotic gene expression dynamics for robust development in C. elegans

    Benjamin P Weaver, Rebecca Zabinsky ... Min Han
    A broadly used gene expression regulatory mechanism inactivates targets by CED-3-caspase-mediated proteolysis and works in parallel to miRNAs for diverse non-apoptotic developmental functions.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanistic insights into volatile anesthetic modulation of K2P channels

    Aboubacar Wague, Thomas T Joseph ... Paul M Riegelhaupt
    The volatile anesthetic isoflurane directly binds to the transmembrane domains of the TREK1 channel to allosterically modulate its function.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Changes in mRNA abundance drive shuttling of RNA binding proteins, linking cytoplasmic RNA degradation to transcription

    Sarah Gilbertson, Joel D Federspiel ... Britt Glaunsinger
    Messenger RNA degradation alters protein trafficking to control transcription.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    MicroRNA-mediated repression of nonsense mRNAs

    Ya Zhao, Jimin Lin ... Ligang Wu
    microRNAs can serve as a surveillance system to repress nonsense mRNAs by recognizing miRNA-responsive elements in the open reading frame region downstream of the premature termination codon.
    1. Neuroscience

    Learning induces the translin/trax RNase complex to express activin receptors for persistent memory

    Alan Jung Park, Robbert Havekes ... Ted Abel
    Combination of in vitro and in vivo approaches reveal how learning suppresses the microRNA system to trigger de novo synthesis of plasticity proteins, a missing link in the current model of microRNA-mediated translation in persistent synaptic plasticity and memory.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    A FYVE zinc finger domain protein specifically links mRNA transport to endosome trafficking

    Thomas Pohlmann, Sebastian Baumann ... Michael Feldbrügge
    An endosomal component employs a novel PAM2-like motif to recruit a key RNA-binding protein, which explains how mRNAs and associated ribosomes are attached to endosomes during coupled transport.
    1. Chromosomes and Gene Expression

    Cotranslational microRNA mediated messenger RNA destabilization

    Trinh To Tat, Patricia A Maroney ... Timothy W Nilsen
    MicroRNAs stimulate the decay of targeted mRNAs while they are associated with translating ribosomes.
    1. Developmental Biology

    Regionally distinct trophoblast regulate barrier function and invasion in the human placenta

    Bryan Marsh, Yan Zhou ... Robert Blelloch
    Single cell RNA-sequencing of distinct regions of the human placenta identifies a smooth chorion-specific cytotrophoblast population responsible for unique functions of the smooth chorion, including acting as a barrier and restricting invasion.
    1. Plant Biology

    Uncovering a novel function of the CCR4-NOT complex in phytochrome A-mediated light signalling in plants

    Philipp Schwenk, David J Sheerin ... Andreas Hiltbrunner
    The light-activated plant photoreceptor phytochrome A binds to NOT9B to displace it from the CCR4-NOT complex, thereby de-repressing light signalling.

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