The depletion of a new class of putative histone methyltransferases, including MET-2, SET-6, SET-19, SET-20, SET-21, SET-32, and SET-33, induced synergistic lifespan extension in daf-2 animals to an average lifespan nearly three times that of wild-type animals.

PHF13 interacts with transcriptional complexes containing RNA polymerase II to recruit/stabilize them at H3K4me2/3 containing active or bivalent promoters.

The transgenerational inheritance of lifespan is facilitated by the accumulation of repressive chromatin across generations.

Two SET-domain containing proteins regulate H3K4me3 by their binding to H3K4me3 through their PHD domain and directly regulate expression of a subset of genes.

Set1 has roles in chromatin organization and transcriptome control that are largely independent of histone H3 lysine 4 methylation.

The maternally provided histone demethylase LSD1/KDM1A has an instrumental role at the beginning of life, shaping the histone methylation landscape and the transcriptional repertoire of the early mouse embryo.

In the model plant Arabidopsis thaliana genome dynamic exchanges of histone variants control the organization of histone modifications into chromatin states, acting as molecular landmarks.

The histone modification H3K9me2 marks peripheral heterochromatin and ensures positional information is safeguarded through cell division such that individual lamina-associated domains are re-established at the nuclear periphery in daughter nuclei.

Heterochromatin is established at nucleation sites associated with open chromatin and RNA transcripts and matures into stable domains if they are found near transposable elements targeted by maternally deposited piRNAs.