484 results found
    1. Evolutionary Biology
    2. Genetics and Genomics

    Haplotypes spanning centromeric regions reveal persistence of large blocks of archaic DNA

    Sasha A Langley, Karen H Miga ... Charles H Langley
    Genomic polymorphism across centromeric regions of humans is organized into large-scale haplotypes with great diversity, including entire Neanderthal centromeres.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    The origins and relatedness structure of mixed infections vary with local prevalence of P. falciparum malaria

    Sha Joe Zhu, Jason A Hendry ... Gil McVean
    Variation in the rate of mixed infections by malaria parasites and the relatedness structure among infecting strains reveals diversity in local epidemiological processes.
    1. Genetics and Genomics

    Introduction of a male-harming mitochondrial haplotype via ‘Trojan Females’ achieves population suppression in fruit flies

    Jonci Nikolai Wolff, Neil J Gemmell ... Damian K Dowling
    Mitochondrial genomes harbor male-fertility-reducing mutations that can be harnessed to control population viability as a novel approach to control economic and environmental pests.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Repeated origins, widespread gene flow, and allelic interactions of target-site herbicide resistance mutations

    Julia M Kreiner, George Sandler ... Stephen I Wright
    The spread of herbicide resistance in one of the most problematic weeds in North America occurs through both recent, repeated mutational origins and gene flow across an international network of agricultural fields.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Natural variation in autumn expression is the major adaptive determinant distinguishing Arabidopsis FLC haplotypes

    Jo Hepworth, Rea L Antoniou-Kourounioti ... Caroline Dean
    Variation in autumnal expression from starting expression levels and initial cold-down-regulation, rather than epigenetic silencing, is the major field variable conferred by worldwide haplotypes of the floral repressor gene, FLC.
    1. Genetics and Genomics

    Non-allelic gene conversion enables rapid evolutionary change at multiple regulatory sites encoded by transposable elements

    Christopher E Ellison, Doris Bachtrog
    Fully functional regulatory elements can arise rapidly from transposable elements via a novel route where non-allelic gene conversion can act to speed up the evolutionary fine-tuning of regulatory elements.
    1. Plant Biology

    Natural haplotypes of FLM non-coding sequences fine-tune flowering time in ambient spring temperatures in Arabidopsis

    Ulrich Lutz, Thomas Nussbaumer ... Claus Schwechheimer
    Gene expression changes associated with polymorphisms in non-coding sequences of the flowering time regulator FLM directly influence flowering time in ambient temperature in Arabidopsis over an extended vegetative period.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Clusters of polymorphic transmembrane genes control resistance to schistosomes in snail vectors

    Jacob A Tennessen, Stephanie R Bollmann ... Michael Scott Blouin
    A region of the Biomphalaria genome, containing highly divergent haplotypes with different combinations of transmembrane genes, strongly impacts whether these snails can transmit parasitic schistosomes.
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    1. Immunology and Inflammation

    Expression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding

    Paul E Chappell, El Kahina Meziane ... Jim Kaufman
    The number of different peptides presented by major histocompatibility complex class I molecules to the immune system's T lymphocytes is inversely correlated with cell surface expression and is strongly associated with the response to infectious disease.
    1. Genetics and Genomics
    2. Evolutionary Biology

    Admixture into and within sub-Saharan Africa

    George BJ Busby, Gavin Band ... Malaria Genomic Epidemiology Network
    Gene flow analysis reveals that the genomes of most sub-Saharan populations are the result of recent historical admixture events.

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