2,101 results found
    1. Chromosomes and Gene Expression

    Regulation of alternative polyadenylation by Nkx2-5 and Xrn2 during mouse heart development

    Keisuke Nimura, Masamichi Yamamoto ... Yasufumi Kaneda
    A tissue-specific transcription factor is involved in the regulation of alternative polyadenylation in conjunction with a transcription termination factor.
    1. Developmental Biology
    2. Genetics and Genomics

    Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development

    Scott A Rankin, Jeffrey D Steimle ... Aaron M Zorn
    Epistatic analysis in Xenopus and mouse embryos reveals an evolutionarily conserved gene regulatory network downstream of the transcription factor Tbx5 and retinoic acid that coordinates cardiac and pulmonary development.
    1. Developmental Biology

    Calcium handling precedes cardiac differentiation to initiate the first heartbeat

    Richard CV Tyser, Antonio MA Miranda ... Paul R Riley
    High-resolution live imaging reveals how and when the mouse heart first starts to beat during development and how the onset of beating impacts on heart muscle cell maturation and heart formation.
    1. Developmental Biology

    Live imaging of heart tube development in mouse reveals alternating phases of cardiac differentiation and morphogenesis

    Kenzo Ivanovitch, Susana Temiño, Miguel Torres
    Tissue-level coordination of cardiac progenitor cells in the early mouse embryo produces a temporal compartmentalization of differentiation and morphogenesis essential for heart tube formation.
    1. Developmental Biology

    SORBS2 is a genetic factor contributing to cardiac malformation of 4q deletion syndrome patients

    Fei Liang, Bo Wang ... Zhen Zhang
    Combined evidence of human genetics, in vitro cardiomyocyte differentiation, and mouse model indicates that SORBS2 is a regulator of second heart field development and its deficiency causes seemingly opposite atrial septal defects.
    1. Developmental Biology

    Coronary blood vessels from distinct origins converge to equivalent states during mouse and human development

    Ragini Phansalkar, Josephine Krieger ... Kristy Red-Horse
    Endothelial cells from separate cardiac lineages start off in distinct transcriptional states, but over the course of development converge into transcriptional and functional states which are unrelated to lineage and which are conserved between mouse and human.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    The long noncoding RNA Charme supervises cardiomyocyte maturation by controlling cell differentiation programs in the developing heart

    Valeria Taliani, Giulia Buonaiuto ... Monica Ballarino
    The lncRNA pCharme controls the expression of cardiomyocyte maturation genes and heart development by orchestrating the formation of MATR3-enriched nuclear condensates.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Combined lineage tracing and scRNA-seq reveals unexpected first heart field predominance of human iPSC differentiation

    Francisco X Galdos, Carissa Lee ... Sean M Wu
    TBX5 lineage tracing and high resolution single cell transcriptomics uncover the predominance of first heart field development during human-induced pluripotent stem cell cardiac differentiation.
    1. Developmental Biology

    Early patterning and specification of cardiac progenitors in gastrulating mesoderm

    W Patrick Devine, Joshua D Wythe ... Benoit G Bruneau
    Multipotent cardiac precursors within a population of mesoderm are rapidly fated to specific anatomic locations in the developing mouse heart.
    1. Developmental Biology

    The myocardium utilizes a platelet-derived growth factor receptor alpha (Pdgfra)–phosphoinositide 3-kinase (PI3K) signaling cascade to steer toward the midline during zebrafish heart tube formation

    Rabina Shrestha, Tess McCann ... Joshua Bloomekatz
    Research on heart tube assembly using zebrafish reveals a pivotal role for intrinsic Pdgfra–PI3K signaling in steering the movement of the myocardium and polarizing myocardial cell protrusions.

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