46 results found
    1. Genetics and Genomics

    The rise and fall of the Phytophthora infestans lineage that triggered the Irish potato famine

    Kentaro Yoshida, Verena J Schuenemann ... Hernán A Burbano
    The strain of Phytophthora infestans that caused the Great Famine in the late 1840s was caused by a single genotype that is distinct from, but closely related to, the most prevalent modern genotype.
    1. Stem Cells and Regenerative Medicine

    The follicle epithelium in the Drosophila ovary is maintained by a small number of stem cells

    Jocelyne Fadiga, Todd G Nystul
    Just 2-4 follicle stem cells maintain each follicle epithelium in the Drosophila ovary, and they reside within a single ring at the anterior edge of the tissue.
    1. Genetics and Genomics

    Genomics: The early days of late blight

    Paul RJ Birch, David EL Cooke
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    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Adult stem cells and niche cells segregate gradually from common precursors that build the adult Drosophila ovary during pupal development

    Amy Reilein, Helen V Kogan ... Daniel Kalderon
    Somatic stem and niche cells in the Drosophila ovary develop from common precursors through regulated proliferative expansion, followed by acquisition of position-specific behaviors, rather than through rigid early specification events.
    1. Developmental Biology

    Electron transport chain biogenesis activated by a JNK-insulin-Myc relay primes mitochondrial inheritance in Drosophila

    Zong-Heng Wang, Yi Liu ... Hong Xu
    An insulin-Myc feed-forward loop triggered by transient JNK boosts transcription of genes essential for mitochondrial respiration and biogenesis during early oogenesis to support massive mtDNA replication and inheritance in Drosophila.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Opposing JAK-STAT and Wnt signaling gradients define a stem cell domain by regulating differentiation at two borders

    David Melamed, Daniel Kalderon
    Graded Wnt and JAK-STAT signals regulate the division rate, AP location and differentiation of Drosophila ovarian follicle stem cells to define a domain of stem cells maintained by population asymmetry.
    1. Developmental Biology
    2. Genetics and Genomics

    Drosophila p53 isoforms have overlapping and distinct functions in germline genome integrity and oocyte quality control

    Ananya Chakravarti, Heshani N Thirimanne ... Brian R Calvi
    Drosophila p53 protein isoforms function during oogenesis to ensure the integrity of the transmitted genome, a function that is conserved to humans.
    1. Developmental Biology

    Neuronal octopamine signaling regulates mating-induced germline stem cell increase in female Drosophila melanogaster

    Yuto Yoshinari, Tomotsune Ameku ... Ryusuke Niwa
    Genetic analyses using the fruit fly illustrate how neuronal system couples germline stem cell increase to an external cue, which is mating, through stem cell niche signaling.
    1. Developmental Biology
    2. Genetics and Genomics

    The GATOR complex regulates an essential response to meiotic double-stranded breaks in Drosophila

    Youheng Wei, Lucia Bettedi ... Mary A Lilly
    The GATOR complex regulates TORC1 activity during meiosis.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    EGFR signaling promotes self-renewal through the establishment of cell polarity in Drosophila follicle stem cells

    Angela Castanieto, Michael J Johnston, Todd G Nystul
    The specification of cell polarity is essential for self-renewal and the segregation of stem-cell and daughter-cell fates in an epithelial stem cell lineage.

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