265 results found
    1. Neuroscience

    Heritability and cross-species comparisons of human cortical functional organization asymmetry

    Bin Wan, Şeyma Bayrak ... Sofie L Valk
    Human brain suggests an asymmetric organization along a functional cortical axis describing a hierarchical functional trajectory from perceptual/action to abstract cognition, which is heritable and comparable with macaque brain, suggesting (phylo)genetic conservation and adaptation.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Heritability enrichment in context-specific regulatory networks improves phenotype-relevant tissue identification

    Zhanying Feng, Zhana Duren ... Yong Wang
    Integrating chromatin accessibility and gene expression data into context-specific regulatory networks can provide better regulatory categories for heritability enrichment and relevant tissue identification.
    1. Genetics and Genomics

    Human genetic analyses of organelles highlight the nucleus in age-related trait heritability

    Rahul Gupta, Konrad J Karczewski ... Vamsi K Mootha
    Although cellular organelles show a functional deterioration in aging, genetic loci associated with common age-associated disease instead nominate nuclear transcription factors across several age-related diseases.
    1. Neuroscience

    The heritability of multi-modal connectivity in human brain activity

    Giles L Colclough, Stephen M Smith ... Mark W Woolrich
    Genes play an important role in determining the strength of functional connectivity in the human brain, and seem to outweigh the contribution from the developmental environment.
    1. Genetics and Genomics

    Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994

    Aline Jelenkovic, Yoon-Mi Hur ... Karri Silventoinen
    Genetic variance of adult human height shows a generally increasing trend across the birth-year cohorts but heritability estimates do not present any clear pattern of secular changes over a century.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Genetics of trans-regulatory variation in gene expression

    Frank Wolfgang Albert, Joshua S Bloom ... Leonid Kruglyak
    A genetic mapping study in more than 1000 yeast individuals reveals the complexity of trans-acting genetic influences on transcriptome variation in unprecedented depth and detail.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Key features of the genetic architecture and evolution of host-microbe interactions revealed by high-resolution genetic mapping of the mucosa-associated gut microbiome in hybrid mice

    Shauni Doms, Hanna Fokt ... John F Baines
    Genetic variation influencing the gut microbiome is abundant among incipient mammalian host species, and cospeciating bacterial taxa display a unique genetic architecture.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The lingering effects of Neanderthal introgression on human complex traits

    Xinzhu Wei, Christopher R Robles ... Sriram Sankararaman
    Genetic variants introgressed into modern humans from Neanderthals tend to be depleted in their contribution to heritable trait variation relative to modern human variants consistent with the action of purifying selection.
    1. Genetics and Genomics

    GWAS of three molecular traits highlights core genes and pathways alongside a highly polygenic background

    Nasa Sinnott-Armstrong, Sahin Naqvi ... Jonathan K Pritchard
    Across urate, IGF-1, and testosterone, thousands of dispersed variants contribute to heritability, while previously characterized core pathways are highly enriched for associations and reveal feedback mechanisms governing serum biomarker levels.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Genome-wide identification of lineage and locus specific variation associated with pneumococcal carriage duration

    John A Lees, Nicholas J Croucher ... Stephen D Bentley
    Sequence changes in the pneumococcal genome explain most of the variability in duration of asymptomatic carriage with serotype, antibiotic resistance and prophage accounting for the largest effects.

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