156 results found
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    ATRX promotes maintenance of herpes simplex virus heterochromatin during chromatin stress

    Joseph M Cabral, Hyung Suk Oh, David M Knipe
    Epigenetic restriction of herpes simplex virus occurs in a biphasic manner, in which ATRX maintains viral heterochromatin after an initial phase of chromatin deposition.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Rapid localized spread and immunologic containment define Herpes simplex virus-2 reactivation in the human genital tract

    Joshua T Schiffer, David Swan ... Lawrence Corey
    A combination of detailed sampling and mathematical modeling suggests that the response of immune cells to reactivation of herpes simplex virus 2 is extremely rapid and effective within microscopic areas of genital skin.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Insights into herpesvirus assembly from the structure of the pUL7:pUL51 complex

    Benjamin G Butt, Danielle J Owen ... Stephen C Graham
    A conserved viral protein complex that promotes membrane wrapping of nascent herpesvirus particles shows structural similarity to cellular membrane-remodelling proteins, suggesting functional mimicry.
    1. Epidemiology and Global Health
    2. Medicine

    Earlier menarche is associated with a higher prevalence of Herpes simplex type-2 (HSV-2) in young women in rural Malawi

    Judith R Glynn, Ndoliwe Kayuni ... Amelia C Crampin
    Earlier menarche leads to earlier sex, marriage, and sexually transmitted infections, so is a serious disadvantage to the life chances of a young woman.
    1. Microbiology and Infectious Disease
    2. Neuroscience

    Neuronal hyperexcitability is a DLK-dependent trigger of herpes simplex virus reactivation that can be induced by IL-1

    Sean R Cuddy, Austin R Schinlever ... Anna R Cliffe
    Herpes simplex virus reactivates from a latent infection when neurons become hyperexcitable in response to an inflammatory cytokine known to be released during fever and stress.
    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    Structure of the transporter associated with antigen processing trapped by herpes simplex virus

    Michael L Oldham, Nikolaus Grigorieff, Jue Chen
    Herpes simplex virus evades the immune response by inhibiting the TAP transporter with a peptide inhibitor ICP47 that has an extensive interface at the peptide translocation cavity and locks the transporter in an inactive state.
    1. Microbiology and Infectious Disease

    Herpes simplex type 2 virus deleted in glycoprotein D protects against vaginal, skin and neural disease

    Christopher Petro, Pablo A González ... William R Jacobs Jr
    An attenuated Herpes simplex type 2 virus deleted in glycoprotein D can be used as an effective vaccine to provide robust transferable humoral immunity and complete protection in murine intravaginal and skin infection models.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Herpes simplex viral nucleoprotein creates a competitive transcriptional environment facilitating robust viral transcription and host shut off

    Sarah E Dremel, Neal A DeLuca
    Herpes simplex ICP4 preferentially binds to and delineates the viral genome, ultimately resulting in robust viral transcription at the expense of the host.
    1. Microbiology and Infectious Disease

    Virology: Ups and downs in the search for a Herpes simplex virus vaccine

    Silvia Bolland, Susan K Pierce
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    1. Medicine
    2. Microbiology and Infectious Disease

    Sex and prior exposure jointly shape innate immune responses to a live herpesvirus vaccine

    Foo Cheung, Richard Apps ... Jeffrey I Cohen
    In a study of a herpes simplex virus (HSV) vaccine, the combination of sex and prior exposure to the virus resulted in HSV naive women mounting a prominent type I interferon response associated with reduced neutralizing titers to HSV.

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