209 results found
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    The Chd1 chromatin remodeler shifts hexasomes unidirectionally

    Robert F Levendosky, Anton Sabantsev ... Gregory D Bowman
    Oriented hexasomes can be generated using the Widom 601 positioning sequence, which enables straightforward production of nucleosomes with asymmetrically modified H2A/H2B dimers.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Distinct and evolutionary conserved structural features of the human nuclear exosome complex

    Piotr Gerlach, Jan M Schuller ... Elena Conti
    Cryo-EM structure and biochemical characterization of the human nuclear exosome reveals its specific properties with respect to the yeast complex, underscoring the evolutionary conservation of the RNA-channeling mechanisms and hMTR4 helicase recruitment.
    1. Microbiology and Infectious Disease

    The host exosome pathway underpins biogenesis of the human cytomegalovirus virion

    Declan L Turner, Denis V Korneev ... Rommel A Mathias
    The HCMV virion envelope is derived from the host exosome membrane, and exosome machinery and export pathways facilitate virion egress.
    1. Chromosomes and Gene Expression

    The budding yeast Centromere DNA Element II wraps a stable Cse4 hemisome in either orientation in vivo

    Steven Henikoff, Srinivas Ramachandran ... Jorja G Henikoff
    A stable tetrameric nucleosome occupies the central segment of each ∼120-bp budding yeast centromere in two rotational phases of both reflectional orientations in vivo.
    1. Biochemistry and Chemical Biology

    Structure and reconstitution of yeast Mpp6-nuclear exosome complexes reveals that Mpp6 stimulates RNA decay and recruits the Mtr4 helicase

    Elizabeth V Wasmuth, John C Zinder ... Christopher D Lima
    The nuclear exosome cofactors Mpp6 and Rrp47 can stimulate exoribonuclease activities of the nuclear RNA exosome and recruit the Mtr4 helicase to promote helicase dependent RNA decay.
    1. Cell Biology

    Exosome complex orchestrates developmental signaling to balance proliferation and differentiation during erythropoiesis

    Skye C McIver, Koichi R Katsumura ... Emery H Bresnick
    An RNA-regulatory machine confers expression and function of a receptor tyrosine kinase to dictate a developmental signaling transition.
    1. Cell Biology

    Annexin A6 mediates calcium-dependent exosome secretion during plasma membrane repair

    Justin Krish Williams, Jordan Matthew Ngo ... Randy Schekman
    Plasma membrane damage causes the release of exosomes from cultured human cells.
    1. Cancer Biology

    Exosome component 1 cleaves single-stranded DNA and sensitizes human kidney renal clear cell carcinoma cells to poly(ADP-ribose) polymerase inhibitor

    Qiaoling Liu, Qi Xiao ... Qingkai Yang
    EXOSC1 acts as an endogenous source of mutation inkidney renalclear cell carcinoma via cleaving single-stranded DNA.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction

    Matthew J Shurtleff, Morayma M Temoche-Diaz ... Randy Schekman
    A cell-free reaction that reconstitutes the selective sorting of a miRNA into exosomes reveals an RNA-binding protein, YBX1, as a critical sorting factor.
    1. Chromosomes and Gene Expression

    Condensin controls cellular RNA levels through the accurate segregation of chromosomes instead of directly regulating transcription

    Clémence Hocquet, Xavier Robellet ... Pascal Bernard
    Contrary to the generally accepted model, condensin maintains proper gene expression by promoting the accurate segregation of chromosomes and the partitioning of the RNA-exosome throughout mitosis, instead of directly regulating transcription.

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