5 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A putative ATPase mediates RNA transcription and capping in a dsRNA virus

    Xuekui Yu, Jiansen Jiang ... Z Hong Zhou
    Atomic structures suggest a novel mechanism for the regulation of mRNA transcription and capping in dsRNA viruses.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural characterization of ribosome recruitment and translocation by type IV IRES

    Jason Murray, Christos G Savva ... Israel S Fernández
    A Internal Ribosomal Entry Site RNA has been visualised by high resolution cryoEM, trapped in the ribosome in an intermediate state of translocation.
    1. Microbiology and Infectious Disease

    Rotavirus VP3 targets MAVS for degradation to inhibit type III interferon expression in intestinal epithelial cells

    Siyuan Ding, Shu Zhu ... Harry B Greenberg
    Rotavirus infection induces phosphorylation and proteasomal degradation of MAVS to suppress host antiviral interferon signaling.
    1. Cell Biology

    A novel biosensor to study cAMP dynamics in cilia and flagella

    Shatanik Mukherjee, Vera Jansen ... Dagmar Wachten
    A new FRET-based cAMP biosensor with nanomolar sensitivity makes it possible to measure cAMP dynamics in miniscule subcellular compartments like cilia and flagella.
    1. Biochemistry and Chemical Biology

    Conformational regulation and target-myristoyl switch of calcineurin B homologous protein 3

    Florian Becker, Simon Fuchs ... Carola Hunte
    The target-myristoyl switch induced by protein-protein interaction is a novel regulatory mechanism for myristoylated EF-hand calcium-binding proteins, in which target binding facilitates exposure of the myristoyl anchor and the association to the lipid membrane in a calcium-independent manner.

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