1,178 results found
    1. Genetics and Genomics

    Histone variants shape chromatin states in Arabidopsis

    Bhagyshree Jamge, Zdravko J Lorković ... Frédéric Berger
    In the model plant Arabidopsis thaliana genome dynamic exchanges of histone variants control the organization of histone modifications into chromatin states, acting as molecular landmarks.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Imaging analysis of six human histone H1 variants reveals universal enrichment of H1.2, H1.3, and H1.5 at the nuclear periphery and nucleolar H1X presence

    Monica Salinas-Pena, Elena Rebollo, Albert Jordan
    Imaging analysis confirms ChIP-Seq data on the distinct genomic distribution of histone H1 variants in AT-rich, nuclear peripheral regions (H1.2, H1.3, H1.5, H1.0) or GC-rich, throughout the nucleus (H1.4, H1X).
    1. Neuroscience

    The activity-dependent histone variant H2BE modulates the life span of olfactory neurons

    Stephen W Santoro, Catherine Dulac
    A genome-organizing protein that is present only in the olfactory system of mice has been found to orchestrate changes in the relative numbers of different odor-sensing neurons on the basis of how active these neurons are.
    1. Immunology and Inflammation

    Histone Deacetylase 7 mediates tissue-specific autoimmunity via control of innate effector function in invariant Natural Killer T Cells

    Herbert G Kasler, Intelly S Lee ... Eric Verdin
    The development of Natural Killer T Cells is controlled by Histone Deacetylase 7, a function that combined with its known role in thymic negative selection provides a potential mechanism explaining its association with tissue-specific autoimmunity in humans.
    1. Chromosomes and Gene Expression

    Live-cell single particle imaging reveals the role of RNA polymerase II in histone H2A.Z eviction

    Anand Ranjan, Vu Q Nguyen ... Carl Wu
    Histone variant H2A.Z is deposited near transcription start sites by the chromatin remodeler SWR1 and seems to be removed by RNA polymerase II at an early stage of transcription elongation.
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    1. Structural Biology and Molecular Biophysics

    Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19

    Cheng Dong, Reiko Nakagawa ... Jinrong Min
    Complex structures of Tudor domains of PHF1/19 with H3tK27me3 provide structural basis for preferential recognition of H3tK27me3 over canonical H3K27me3, implicating that H3tK27me3 might be a physiological ligand of PHF1/19.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Constitutive turnover of histone H2A.Z at yeast promoters requires the preinitiation complex

    Michael Tramantano, Lu Sun ... Ed Luk
    The transcription machinery is required for the disassembly of the promoter-proximal H2A.Z nucleosome, contributing to the constitutive histone turnover at yeast promoters.
    1. Chromosomes and Gene Expression

    Integrated analysis of H2A.Z isoforms function reveals a complex interplay in gene regulation

    Assala Lamaa, Jonathan Humbert ... Didier Trouche
    The two H2A.Z isoforms have specific interactors which mediate their differential effects on gene expression.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Genome-wide detection of imprinted differentially methylated regions using nanopore sequencing

    Vahid Akbari, Jean-Michel Garant ... Steven JM Jones
    A genome-wide map of human allele-specific methylation using long-read sequencing detects novel imprinted DNA methylation events and reveals large blocks of subtle parent-of-origin bias in DNA methylation with mutual exclusive allelic H3K36me3 and H3K27me3 histone modifications.
    1. Chromosomes and Gene Expression

    Chromatin structure-dependent histone incorporation revealed by a genome-wide deposition assay

    Hiroaki Tachiwana, Mariko Dacher ... Noriko Saitoh
    A new method using permeabilized cells and recombinant histones enables to analyze histone incorporations at the DNA sequence level.

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