2,522 results found
    1. Genetics and Genomics
    2. Plant Biology

    Evidence for suppression of immunity as a driver for genomic introgressions and host range expansion in races of Albugo candida, a generalist parasite

    Mark McMullan, Anastasia Gardiner ... Jonathan DG Jones
    Hybridization and introgression blur species boundaries and broaden genetic diversity available for adaptation; and widespread introgression underpins the evolution of races of the generalist pathogen Albugo candida that specialise on different host plant species.
    1. Microbiology and Infectious Disease

    Differences across cyclophilin A orthologs contribute to the host range restriction of hepatitis C virus

    Jenna M Gaska, Metodi Balev ... Alexander Ploss
    Incompatibilities between the viral replication machinery and orthologs of the essential host factor cyclophilin A (CypA) contribute to the narrow host range of hepatitis C virus.
    1. Ecology
    2. Microbiology and Infectious Disease

    Variation in the ACE2 receptor has limited utility for SARS-CoV-2 host prediction

    Nardus Mollentze, Deborah Keen ... Daniel G Streicker
    The success of angiotensin-converting enzyme 2 (ACE2)-based predictions of severe acute respiratory syndrome-associated virus 2 (SARS-CoV-2) host range stems from phylogenetic correlation, allowing development of scalable models which predict susceptibility to SARS-CoV-2 and other sarbecoviruses without requiring additional ACE2 sequencing.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    The evolution of a counter-defense mechanism in a virus constrains its host range

    Sriram Srikant, Chantal K Guegler, Michael T Laub
    Bacteriophage can rapidly evolve resistance to anti-phage defense elements in bacteria by amplifying latent counter-defense genes, though this amplification comes at a cost of compensatory deletions that eliminate other counter-defense genes.
    1. Genetics and Genomics

    Codon optimization underpins generalist parasitism in fungi

    Thomas Badet, Remi Peyraud ... Sylvain Raffaele
    Codon optimization through biased synonymous substitutions is a characteristic feature of the genomes of generalist fungal parasites and is associated with the colonization of multiple hosts.
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    1. Evolutionary Biology

    Symptom evolution following the emergence of maize streak virus

    Adérito L Monjane, Simon Dellicour ... Darren P Martin
    Phylogenetic analyses demonstrate an evolutionary trade-off between the amount of harm inflicted by a broad host-range virus and how effectively the virus positions itself within plants to enable onward transmission.
    1. Microbiology and Infectious Disease

    Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats

    Melinda Ng, Esther Ndungo ... Kartik Chandran
    NPC1 is a genetic determinant of filovirus susceptibility in bats, and some variations in bat NPC1 may reflect host adaptations to reduce filovirus replication and virulence.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Towards a unified model of naive T cell dynamics across the lifespan

    Sanket Rane, Thea Hogan ... Andrew J Yates
    Naive CD4 and CD8 T cells in mice increase their survival capacity with age, but their numbers are not homeostatically regulated.
    1. Ecology
    2. Neuroscience

    Unique neural coding of crucial versus irrelevant plant odors in a hawkmoth

    Sonja Bisch-Knaden, Michelle A Rafter ... Bill S Hansson
    The sense of smell of female hawkmoths has evolved to find the intense odor of floral nectar sources as well as inconspicuous scents of oviposition sites within a complex olfactory landscape.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Dissection of affinity captured LINE-1 macromolecular complexes

    Martin S Taylor, Ilya Altukhov ... John LaCava
    The range of molecular forms adopted by L1 retrotransposons reflect a tapestry of lifecycle-permissive and -restrictive host-parasite interactions occurring within cells.

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