120 results found
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A sustained type I IFN-neutrophil-IL-18 axis drives pathology during mucosal viral infection

    Tania Lebratti, Ying Shiang Lim ... Haina Shin
    Type I IFN is a key determinant of pathogenic neutrophil activity and drives tissue pathology through modulation of IL-18 levels during genital HSV infection.
    1. Microbiology and Infectious Disease

    Herpes simplex type 2 virus deleted in glycoprotein D protects against vaginal, skin and neural disease

    Christopher Petro, Pablo A González ... William R Jacobs Jr
    An attenuated Herpes simplex type 2 virus deleted in glycoprotein D can be used as an effective vaccine to provide robust transferable humoral immunity and complete protection in murine intravaginal and skin infection models.
    1. Epidemiology and Global Health
    2. Medicine

    Earlier menarche is associated with a higher prevalence of Herpes simplex type-2 (HSV-2) in young women in rural Malawi

    Judith R Glynn, Ndoliwe Kayuni ... Amelia C Crampin
    Earlier menarche leads to earlier sex, marriage, and sexually transmitted infections, so is a serious disadvantage to the life chances of a young woman.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Rapid localized spread and immunologic containment define Herpes simplex virus-2 reactivation in the human genital tract

    Joshua T Schiffer, David Swan ... Lawrence Corey
    A combination of detailed sampling and mathematical modeling suggests that the response of immune cells to reactivation of herpes simplex virus 2 is extremely rapid and effective within microscopic areas of genital skin.
    1. Medicine
    2. Microbiology and Infectious Disease

    Sex and prior exposure jointly shape innate immune responses to a live herpesvirus vaccine

    Foo Cheung, Richard Apps ... Jeffrey I Cohen
    In a study of a herpes simplex virus (HSV) vaccine, the combination of sex and prior exposure to the virus resulted in HSV naive women mounting a prominent type I interferon response associated with reduced neutralizing titers to HSV.
    1. Microbiology and Infectious Disease

    Virology: Ups and downs in the search for a Herpes simplex virus vaccine

    Silvia Bolland, Susan K Pierce
    Insight
    Formats available:
    • HTML
    • PDF
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Insights into herpesvirus assembly from the structure of the pUL7:pUL51 complex

    Benjamin G Butt, Danielle J Owen ... Stephen C Graham
    A conserved viral protein complex that promotes membrane wrapping of nascent herpesvirus particles shows structural similarity to cellular membrane-remodelling proteins, suggesting functional mimicry.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    The aryl hydrocarbon receptor and interferon gamma generate antiviral states via transcriptional repression

    Tonya Kueck, Elena Cassella ... Paul D Bieniasz
    Distinct antiviral signaling pathways, triggered by the aryl hydrocarbon receptor and Interferon-gamma, converge on CDK/cyclin repression, causing inhibition of viral DNA synthesis.
    1. Microbiology and Infectious Disease
    2. Neuroscience

    Neuronal hyperexcitability is a DLK-dependent trigger of herpes simplex virus reactivation that can be induced by IL-1

    Sean R Cuddy, Austin R Schinlever ... Anna R Cliffe
    Herpes simplex virus reactivates from a latent infection when neurons become hyperexcitable in response to an inflammatory cytokine known to be released during fever and stress.
    1. Cell Biology

    Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP

    Li Zhang, Prashant Rajbhandari ... Peter Tontonoz
    The E3 ubiquitin ligase RNF145 is shown to contribute to crosstalk between the LXR and SREBP-2 pathways in the regulation of cholesterol homeostasis.

Refine your results by:

Type
Research categories