11,431 results found
    1. Evolutionary Biology
    2. Neuroscience

    Quantitative uniqueness of human brain evolution revealed through phylogenetic comparative analysis

    Ian F Miller, Robert A Barton, Charles L Nunn
    The exceptionally large size of the human brain is the result of accelerating evolution towards larger brains in hominins, but is not the product of neocortical expansion.
    1. Neuroscience

    High-resolution imaging of skin deformation shows that afferents from human fingertips signal slip onset

    Benoit P Delhaye, Ewa Jarocka ... Philippe Lefèvre
    Synchronous recording of skin deformations at the contact with a transparent surface and of tactile afferents from the fingertip reveals that afferents signal incipient slip.
    1. Evolutionary Biology

    Rapid evolution of the human mutation spectrum

    Kelley Harris, Jonathan K Pritchard
    Heritable mutations tend to occur within different DNA sequence contexts in different human populations, suggesting that DNA replication and repair often change in efficacy over only a few hundred generations of evolution.
    1. Genetics and Genomics

    Mosaic cis-regulatory evolution drives transcriptional partitioning of HERVH endogenous retrovirus in the human embryo

    Thomas A Carter, Manvendra Singh ... Cédric Feschotte
    A 'phyloregulatory' approach reveals how human endogenous retrovirus type-H, a family of human endogenous retroviruses, diversified its regulatory sequences through multiple mutational mechanisms to partition its transcriptional activity spatially and temporally within the human embryo.
    1. Neuroscience

    High-resolution quantitative and functional MRI indicate lower myelination of thin and thick stripes in human secondary visual cortex

    Daniel Haenelt, Robert Trampel ... Nikolaus Weiskopf
    In vivo quantitative magnetic resonance imaging at ultra-high magnetic field reveals systematic differences of relaxation parameters (R1) within the human secondary visual cortex at the level of the thin-thick-pale stripes system, which points toward higher cortical myelination of pale stripes.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Parallel evolution between genomic segments of seasonal human influenza viruses reveals RNA-RNA relationships

    Jennifer E Jones, Valerie Le Sage ... Seema S Lakdawala
    Phylogenetic relationships between viral RNA segments are distinct between subtypes and lineages of seasonal human influenza A viruses and implicate RNA-RNA relationships as novel drivers of influenza virus evolution.
    1. Evolutionary Biology

    Homoplasy in the evolution of modern human-like joint proportions in Australopithecus afarensis

    Anjali M Prabhat, Catherine K Miller ... Jeremy M DeSilva
    The human-like joint proportions of Australopithecus afarensis evolved independently, making 'Lucy' and her kind the earliest known evolutionary experiment in obligate bipedalism.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Tempo and mode of gene expression evolution in the brain across primates

    Katherine Rickelton, Trisha M Zintel ... Courtney C Babbitt
    Larger phylogenetic context is required to understand human and nonhuman primate brain evolution.
    1. Developmental Biology
    2. Neuroscience

    Evolution and cell-type specificity of human-specific genes preferentially expressed in progenitors of fetal neocortex

    Marta Florio, Michael Heide ... Michael Hiller
    Transcriptomic and genomic analysis provides a resource of 50 primate-specific genes preferentially expressed in neural progenitors of fetal human neocortex, 15 of which are specific to humans.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Uncovering perturbations in human hematopoiesis associated with healthy aging and myeloid malignancies at single-cell resolution

    Marina Ainciburu, Teresa Ezponda ... Felipe Prosper
    Single-cell transcriptomics reveals altered pathways, gene expression dynamics, and activation of transcriptional programs in human early hematopoiesis during healthy aging and myelodysplastic syndromes.

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