89 results found
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Slo1 is the principal potassium channel of human spermatozoa

    Nadja Mannowetz, Natasha M Naidoo ... Polina V Lishko
    Potassium ions enter and leave human sperm cells via a calcium-dependent ion channel that is also pH-independent.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    The Ca2+-activated K+ current of human sperm is mediated by Slo3

    Christoph Brenker, Yu Zhou ... Timo Strünker
    The principal potassium ion channel in human sperm, Slo3, is primarily activated by calcium ions and controls the membrane potential of human sperm by intracellular calcium ion levels rather than intracellular pH.
    1. Cell Biology

    TRPV4 is the temperature-sensitive ion channel of human sperm

    Nadine Mundt, Marc Spehr, Polina V Lishko
    The molecular identity of the temperature-sensitive ion channel of human sperm that ensures depolarization is TRPV4.
    1. Immunology and Inflammation
    2. Medicine

    Transcriptome network analysis implicates CX3CR1-positive type 3 dendritic cells in non-infectious uveitis

    Sanne Hiddingh, Aridaman Pandit ... Jonas JW Kuiper
    CX3CR1-positive dendritic cells are altered in patients with non-infectious uveitis.
    1. Computational and Systems Biology

    Comprehensive and unbiased multiparameter high-throughput screening by compaRe finds effective and subtle drug responses in AML models

    Morteza Chalabi Hajkarim, Ella Karjalainen ... Kyoung-Jae Won
    compaRe can be used to optimize cytometric high-parameter immunophenotypic characterization of heterogeneous cell populations.
    1. Immunology and Inflammation

    Intraocular dendritic cells characterize HLA-B27-associated acute anterior uveitis

    Maren Kasper, Michael Heming ... Gerd Meyer zu Hörste
    Single-cell transcriptomics of intraocular infiltrate in human HLA-B27-associated active anterior uveitis shows a unique composition and phenotype of leukocytes preferentially affecting dendritic cells.
    1. Structural Biology and Molecular Biophysics

    The complete structure of the human TFIIH core complex

    Basil J Greber, Daniel B Toso ... Eva Nogales
    The structure of human transcription factor IIH, a critical DNA repair and transcription initiation factor, has been determined by cryo-electron microscopy.
    1. Developmental Biology

    Induction of human somatostatin and parvalbumin neurons by expressing a single transcription factor LIM homeobox 6

    Fang Yuan, Xin Chen ... Yan Liu
    Inducing expression of a single transcription factor LIM homeobox 6 showed efficient generation of human parvalbumin and somatostatin interneurons.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    A K+-selective CNG channel orchestrates Ca2+ signalling in zebrafish sperm

    Sylvia Fechner, Luis Alvarez ... U Benjamin Kaupp
    Zebrafish sperm display an unusual pathway for Ca2+ signalling.

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