HUWE1 indirectly mediates the return to cellular homeostasis after pro-inflammatory responses, which it does by controling the stability of the immune suppressor tristetraprolin.

The cancer-associated human ubiquitin ligase HUWE1 can adopt an auto-inhibited dimeric state, whose occupancy is regulated by competing intra- and intermolecular interactions of the dimerization region and by the tumor suppressor p14ARF.

Proteasome-mediated degradation of the TATA-box binding protein (TBP) during terminal differentiation is regulated by the E3 ligase Huwe1 and the deubiquitinase USP10.

Tom1 is the ubiquitin ligase in yeast that anchors a protein quality control pathway that rapidly eliminates ribosomal proteins that fail to assemble into ribosomes.

Genetic and protein analyses in vitro and in vivo identifies Id4 as a novel regulator of stem cell quiescence in the adult hippocampus.

A systematic genetic analysis comprising seven genome-wide screens in haploid human cells uncovered new regulatory mechanisms at most levels in the WNT signaling pathway.

MARCH5 mediates a pathway driving MCL1 degradation in response to cellular stress, which sensitizes to BH3 mimetic drugs targeting BCLXL and provides a broadly effective therapeutic strategy for solid tumors.

SPOP-dependent degradation of interferon regulatory factor 1 curtails cell-intrinsic innate immunity, thereby contributing to immune resolution.

The integration of experimental and data mining approaches provides novel insights into deubiquitinating enzymes individually and as a gene family.

SIAH2 and OTUD5 orchestrate DBC1 ubiquitination and degradation under hypoxic conditions.