In depth characterization of gene expression in the mouse hypothalamus will facilitate understanding of the molecular pathways that affect metabolic traits and discovers new genes associated with these pathways.

Single-cell transcriptomic analyses of hypothalamic POMC neurons performed at seven developmental ages revealed marked cellular heterogeneity and divergent developmental pathways into alternative neuronal phenotypes that lack POMC.

Identification of transcriptional changes in the hypothalamus during Influenza A virus infection enhances our understanding of mechanisms underlying long-lasting neurological disturbances, potentially informing future therapeutic interventions and improving patient outcomes.

Single cell RNA–sequencing and neuroanatomical methods reveal unexpected molecular diversity and highly segregated spatial organization of neuronal cell types within the mouse ventral posterior hypothalamus, including the mammillary nuclei.

Zdbf2 is a paternally expressed gene that is mainly expressed in the hypothalamus and promotes appetite and body weight gain in neonates.

Fate-mapping, combined with gain- and loss-of-function approaches, reveal the role of BMP signalling in the spatio-temporal development of the tuberal hypothalamus, a critically important brain region.

CNGA3 is a cold-potentiated ion channel that confers cold sensitivity to mouse hypothalamic neurons, whereas CNGA3 from hibernating ground squirrels is cold-insensitive.

Foxb1-expressing hypothalamic neurons in the parvafox nucleus and the dorsal premammillary nucleus both contribute to behavioral and physiological components associated with defensive behavior.

Hypothalamic stress effector neurons rapidly change activity patterns via recurrent inhibition, representing state-dependent activity switch between baseline and elevated stress levels.

Estrogen receptor alpha in the hypothalamus is required for the effects of chronic tamoxifen treament on gene expression, thermoregulation, bone, and movement in mice.