14,745 results found
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Id4 promotes the elimination of the pro-activation factor Ascl1 to maintain quiescence of adult hippocampal stem cells

    Isabelle Maria Blomfield, Brenda Rocamonde ... Noelia Urbán
    Genetic and protein analyses in vitro and in vivo identifies Id4 as a novel regulator of stem cell quiescence in the adult hippocampus.
    1. Cancer Biology

    Registered report: IDH mutation impairs histone demethylation and results in a block to cell differentiation

    Adam D Richarson, David A Scott ... Reproducibility Project: Cancer Biology
    1. Neuroscience

    Id2 GABAergic interneurons comprise a neglected fourth major group of cortical inhibitory cells

    Robert Machold, Shlomo Dellal ... Bernardo Rudy
    Id2 GABAergic interneurons represent a fourth major group of local inhibitory neurons that includes neurogliaform cells, and these neurons can be targeted using intersectional genetics, revealing their distinctive connectivity and in vivo activity properties.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair

    Shintaro Ide, Yoshihiko Kobayashi ... Tomokazu Souma
    Ferroptotic stress enhances the accumulation of damage-associated inflammatory proximal tubular cell state, thereby promoting maladaptive renal repair and the AKI-to-CKD transition.
    1. Cancer Biology

    Replication Study: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

    Megan Reed Showalter, Jason Hatakeyama ... Reproducibility Project: Cancer Biology
    Editors' Summary: This Replication Study has reproduced important parts of the original paper.
    1. Cell Biology
    2. Immunology and Inflammation

    Distinct mechanisms define murine B cell lineage immunoglobulin heavy chain (IgH) repertoires

    Yang Yang, Chunlin Wang ... Leonore A Herzenberg
    The B-1a cell heavy chain antibody repertoire differs dramatically from the follicular and marginal zone B cell repertoire and is defined by distinct mechanisms driven by self antigens rather than antigens derived from the microbiota.
    1. Immunology and Inflammation

    Different B cell subpopulations show distinct patterns in their IgH repertoire metrics

    Marie Ghraichy, Valentin von Niederhäusern ... Johannes Trück
    IgH repertoires of physically sorted and bioinformatically selected B cell subpopulations overlap and are characterised by distinct repertoire characteristics, while certain repertoire features correlate with the position of the constant region on the IgH locus.
    1. Neuroscience

    Learning-related population dynamics in the auditory thalamus

    Ariel Gilad, Ido Maor, Adi Mizrahi
    The auditory thalamus encodes higher-order information that emerges while learning an auditory discrimination task.
    1. Plant Biology
    2. Structural Biology and Molecular Biophysics

    Structure of Dunaliella photosystem II reveals conformational flexibility of stacked and unstacked supercomplexes

    Ido Caspy, Maria Fadeeva ... Nathan Nelson
    Photosystem II, the pigment-protein complex responsible for water oxidation in photosynthesis, was found to exist in two different core conformations with altered antennae connectivity.

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