4,562 results found
    1. Genetics and Genomics

    Mutations primarily alter the inclusion of alternatively spliced exons

    Pablo Baeza-Centurion, Belén Miñana ... Ben Lehner
    Deep mutagenesis reveals that mutations rarely alter the inclusion of highly-included exons.
    1. Neuroscience

    Decreased motor cortex excitability mirrors own hand disembodiment during the rubber hand illusion

    Francesco della Gatta, Francesca Garbarini ... Paola Borroni
    An illusion in which individuals feel that their own hand no longer belongs to them may reflect a temporary reduction in the brain’s ability to control the movement of the hand.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Phosphoregulation accommodates Type III secretion and assembly of a tether of ER-Chlamydia inclusion membrane contact sites

    Rachel J Ende, Rebecca L Murray ... Isabelle Derré
    To establish membrane contacts between its vacuole and the endoplasmic reticulum, the obligate intracellular bacterial pathogen Chlamydia trachomatis has evolved complex molecular strategies to mimic emerging regulatory processes that control contact-dependent organelle–organelle communication.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Ebola virus sequesters IRF3 in viral inclusion bodies to evade host antiviral immunity

    Lin Zhu, Jing Jin ... Cheng Cao
    Ebola virus VP35 protein evades host antiviral immunity by interacting with STING to sequester IRF3 into inclusion bodies and inhibit type I interferon production.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    The forgotten people: Hepatitis B virus (HBV) infection as a priority for the inclusion health agenda

    Emily Martyn, Sarah Eisen ... Philippa C Matthews
    Hepatitis B virus infection is a neglected challenge among communities who are under-served by conventional models of healthcare, requiring enhanced interventions to reduce inequity.
    1. Cell Biology
    2. Developmental Biology

    Philosophy of Biology: The analysis of living systems can generate both knowledge and illusions

    Antony M Jose
    By thinking about experimental techniques in terms of six broad approaches – perturbation, visualization, substitution, characterization, reconstitution, and simulation – researchers may be able to generate more reliable inferences.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Structural basis for the hijacking of endosomal sorting nexin proteins by Chlamydia trachomatis

    Blessy Paul, Hyun Sung Kim ... Brett M Collins
    Chlamydia hijacks membrane trafficking proteins of the human host via the cytoplasmic domain of a secreted transmembrane protein.
    1. Neuroscience

    Uncertainty-based inference of a common cause for body ownership

    Marie Chancel, H Henrik Ehrsson, Wei Ji Ma
    Behavioral and computational results show that the perception of our body as our own depends on Bayesian probabilistic reasoning that take into account the variations in sensory uncertainty when integrating visual and somatosensory cues.
    1. Genetics and Genomics

    Equity, Diversity and Inclusion: Targeted action to increase inclusion at the Wellcome Sanger Institute

    Saher Ahmed, David J Adams ... Maria Augusta Arruda
    The Sanger Excellence Fellowship has been established to increase the representation of researchers with Black-heritage backgrounds at a leading research centre in the UK.
  1. Meta-Research: A 10-year follow-up study of sex inclusion in the biological sciences

    Nicole C Woitowich, Annaliese Beery, Teresa Woodruff
    Sex-inclusive research practices have increased in many biological disciplines over the past decade, yet critical sex-based analyses and reporting have remained stagnant in most of these disciplines.

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