A computational model of the initial visual encoding together with Bayesian image reconstruction quantifies how that encoding, combined with the statistical regularities of natural images, shapes key aspects of visual perception.

The visual message conveyed by retinal neurons to the brain when signaling natural scenes resembles the individual receptive fields only when viewed in context of the neuronal population.

2D template matching complements 3D template matching of tomograms, providing fast and specific detection of molecules in cryo-EM images of cells, as well as generating 3D reconstructions from detected targets.

Using GPUs for the costly computations in cryo-EM enables structure determination in mere days on a single workstation.

A new pipeline of electron microscopy techniques reduces the time required to visualize genetically targeted neurons and their connections by two orders of magnitude.

A novel strategy for reproducible cryo-EM sample preparation with minimal sample volumes.

A synaptic resolution somatotopic map of nearly all mechanosensory neurons on the Drosophila head that individually elicit aimed grooming of specific head locations and collectively elicit a head grooming sequence.

High-resolution fluorescence imaging of the complete mouse brain enables many neurons to be efficiently visualized in their entirety, revealing all targets of neurons that project widely across the brain.

While electron microscopic helical reconstruction is a powerful technique in structural biology, mistakes can be made in determining the helical symmetry, leading to structures that are artifactual.

FIB-SEM is used to identify comprehensively and reconstruct 192 neurons and their complete connectome for glomerulus VA1v of the Drosophila antennal lobe, in particular to reconstruct its local interneurons.