Genetically engineered, CD73-redirected human NK cells show potent antitumor activity in vivo by impairing adenosinergic activity of CD73 in cancer.

A high-throughput mitochondrial phenotyping approach quantifies mitochondrial features among purified human immune cell subtypes and provides foundational knowledge to map inter- and intra-individual variation in mitochondrial energetics with high biological specificity.

Among European children, shorter telomere length and older DNA methylation age relative to chronological age were associated with poorer behaviors, while older age, as predicted by a novel immunometabolic clock relative to chronological age, was associated with greater cognitive maturity.

WASp is an immunometabolic regulator of human myeloid cells and regulates autophagy and mitochondrial homeostasis.

Integrative multi-omics reveals global dysregulation in hepatic metabolism during prolonged sepsis.

Lifetime imaging of endogenous metabolic coenzymes is sensitive to dynamic changes in macrophage activation in a live animal, providing a label-free imaging approach to study immunometabolism in vivo with single-cell, spatial, and temporal resolution.

A novel type of metabolic syndrome, derived from computational modeling of phenotypic diversity in normal physiological settings, increases the risk of certain complex diseases.

Diverse components of the tumor microenvironment affect T cell metabolism in ways that are crucial to improving immunotherapy.

Macrophage Bmal1 controls the timing of the glycolytic to oxidative metabolism transition that dictates the extent of Hif-1a activation and the associated inflammatory response.

Ketogenic diet protects against coronavirus-infected aged mice, which, like humans, are significantly more susceptible to infections, by deactivating NLRP3 inflammasome, reducing pathogenic monotypes, and expanding γδ T cells in the lung.