11,226 results found
    1. Neuroscience

    Human motor fatigability as evoked by repetitive movements results from a gradual breakdown of surround inhibition

    Marc Bächinger, Rea Lehner ... Nicole Wenderoth
    Motor fatigability is associated with a decrease in inhibition throughout the motor network, suggesting that selective inhibitory control is a key mechanism to maintain motor efficiency during repetitive movements.
    1. Neuroscience

    Neural activity related to volitional regulation of cortical excitability

    Kathy Ruddy, Joshua Balsters ... Nicole Wenderoth
    Changing brain state using feedback from transcranial magnetic stimulation, by training participants to increase or decrease how excitable their motor pathways are.
    1. Cancer Biology

    Extracellular signal-regulated kinase mediates chromatin rewiring and lineage transformation in lung cancer

    Yusuke Inoue, Ana Nikolic ... William W Lockwood
    Lineage transformation in lung cancer is dictated by ERK activity and requires permissive chromatin alterations in the context of targeted therapy resistance.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Global divergence in critical income for adult and childhood survival: analyses of mortality using Michaelis–Menten

    Ryan J Hum, Prabhat Jha ... Yu-Ling Cheng
    A mathematical model based on enzyme kinetics shows how the relationships between life expectancy, survival rates for children and adults, and national income change over time.
    1. Neuroscience

    Striatal fast-spiking interneurons selectively modulate circuit output and are required for habitual behavior

    Justin K O'Hare, Haofang Li ... Nicole Calakos
    Fast-spiking interneurons of the dorsolateral striatum are found to provide a microcircuit mechanism driving the circuit properties and behavioral adaptations that characterize habit.
    1. Developmental Biology
    2. Genetics and Genomics

    The rosetteless gene controls development in the choanoflagellate S. rosetta

    Tera C Levin, Allison J Greaney ... Nicole King
    The establishment of forward genetics in S. rosetta reveals the first gene known to be required for choanoflagellate multicellular development.
    1. Cell Biology
    2. Evolutionary Biology

    The wtf4 meiotic driver utilizes controlled protein aggregation to generate selective cell death

    Nicole L Nuckolls, Anthony C Mok ... Sarah E Zanders
    The Wtf4 antidote protein assembles with the Wtf4 poison protein and promotes the transportation of the assembled proteins to the vacuole for sequestration or destruction.
    1. Epidemiology and Global Health

    Understanding disruptions in cancer care to reduce increased cancer burden

    Kia L Davis, Nicole Ackermann ... Vetta L Sanders Thompson
    Many people canceled cancer screening and cancer care appointments during the pandemic, but cancer prevention and control practitioners must proactively facilitate their return to care to avoid widening cancer health disparities.
    1. Chromosomes and Gene Expression

    A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics

    Nicole A Rapicavoli, Kun Qu ... Howard Y Chang
    A long non-coding RNA regulates the expression of genes that encode proteins involved in the inflammatory response.
    1. Neuroscience

    Bayesian inference of population prevalence

    Robin AA Ince, Angus T Paton ... Philippe G Schyns
    Bayesian estimation of the proportion of the population that would show an effect in an experiment provides a broadly applicable alternative to standard null hypothesis tests on the population mean with several advantages.

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