2,365 results found
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Drosophila SUMM4 complex couples insulator function and DNA replication control

    Evgeniya N Andreyeva, Alexander V Emelyanov ... Dmitry V Fyodorov
    Biochemical and biological characterization of insulator complex SUMM4 reveals that, in addition to disrupting enhancer–promoter interactions and establishing chromatin barriers, it functions to delay DNA replication, thus implicating architectural proteins in shaping spatiotemporal patterns of replication.
    1. Chromosomes and Gene Expression

    Dynamic spreading of chromatin-mediated gene silencing and reactivation between neighboring genes in single cells

    Sarah Lensch, Michael H Herschl ... Lacramioara Bintu
    In a synthetic system, spreading of chromatin-mediated silencing to nearby genes depends on distance and can bypass genetic insulators, while reactivation after release of gene targeting is coordinated by insulators and promoters.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Controlling gene activation by enhancers through a drug-inducible topological insulator

    Taro Tsujimura, Osamu Takase ... Keiichi Hishikawa
    A novel synthetic DNA cassette of CTCF-binding sites combined with the drug-controllable induction system of heterochromatin enabled switchable blocking of chromatin conformation and gene-enhancer interaction.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Computational prediction of CTCF/cohesin-based intra-TAD loops that insulate chromatin contacts and gene expression in mouse liver

    Bryan J Matthews, David J Waxman
    Certain types of 3D chromatin loops are easy to predict from existing or easily obtainable 2D information, which benefits gene expression studies in tissues/cells/organisms without extensive pre-existing 3D information.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Convergence of topological domain boundaries, insulators, and polytene interbands revealed by high-resolution mapping of chromatin contacts in the early Drosophila melanogaster embryo

    Michael R Stadler, Jenna E Haines, Michael B Eisen
    Fruit fly chromosomes are divided into discrete structural domains by regions of decompacted chromatin, suggesting a novel model for the formation of a known class of genetic elements.
    1. Neuroscience

    Anterior insular cortex plays a critical role in interoceptive attention

    Xingchao Wang, Qiong Wu ... Jin Fan
    Anterior insular cortex activity predicts how well we attend to our bodily signals, while lesions to this brain region disrupt this ability.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    lncRNA read-through regulates the BX-C insulator Fub-1

    Airat Ibragimov, Xin Yang Bing ... Paul Schedl
    A novel mechanism of gene regulation is discovered wherein a specific long non-coding RNA abolishes the blocking activity of chromatin insulator in the Drosophila HOX gene cluster.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Transcription mediated insulation and interference direct gene cluster expression switches

    Tania Nguyen, Harry Fischl ... Jane Mellor
    The formation of mutually exclusive coding and non-coding transcription units contributes to transcriptional interference and insulation at gene clusters and manages state-switching in response to environmental change.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Establishment and maintenance of heritable chromatin structure during early Drosophila embryogenesis

    Shelby A Blythe, Eric F Wieschaus
    The patterns of chromatin architecture that underlie the initial embryonic cell fate decisions are established during a period of intense cell cycle activity, and these patterns are stably maintained even in highly condensed mitotic chromatin.
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    1. Neuroscience

    A whole-brain connectivity map of mouse insular cortex

    Daniel A Gehrlach, Caroline Weiand ... Nadine Gogolla
    Whole-brain in- and outputs of inhibitory and excitatory neurons located in distinct subregions of the mouse insular cortex were mapped using viral-tracing strategies.

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