597 results found
    1. Structural Biology and Molecular Biophysics
    2. Plant Biology

    Structural basis of pathogen recognition by an integrated HMA domain in a plant NLR immune receptor

    A Maqbool, H Saitoh ... MJ Banfield
    Structure/function studies of a plant pathogen effector in complex with a host disease resistance protein domain reveal the molecular basis for recognition and underpin future engineering of immunity in crops.
    1. Microbiology and Infectious Disease

    Integrated sensing of host stresses by inhibition of a cytoplasmic two-component system controls M. tuberculosis acute lung infection

    John A Buglino, Gaurav D Sankhe ... Michael S Glickman
    M. tuberculosis, the bacterium that causes the disease tuberculosis, uses a signaling system that senses multiple products of the host's immune system to modify gene expression to colonize the lung.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Conformational changes in twitchin kinase in vivo revealed by FRET imaging of freely moving C. elegans

    Daniel Porto, Yohei Matsunaga ... Hang Lu
    Quantitative FRET imaging in moving C. elegans shows that stretch-unfolding of twitchin kinase occurs in the active muscle, whereby mechanical activity titrates the signaling pathway of this cytoskeletal kinase.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Single-molecule fluorimetry and gating currents inspire an improved optical voltage indicator

    Jeremy S Treger, Michael F Priest, Francisco Bezanilla
    ArcLight, a popular optogenetic reporter of voltage, is studied at both single-molecule and macroscopic levels, which leads to new mechanistic understanding and to the rational design of a faster reporter.
    1. Neuroscience
    2. Physics of Living Systems

    Gigapixel imaging with a novel multi-camera array microscope

    Eric E Thomson, Mark Harfouche ... Eva A Naumann
    A new multi camera imaging platform simultaneously captures large-area, high-resolution video of unconstrained small model organisms and provides behavioral measurements that span multiple spatial scales.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Molecular basis for functional connectivity between the voltage sensor and the selectivity filter gate in Shaker K+ channels

    Carlos AZ Bassetto, João Luis Carvalho-de-Souza, Francisco Bezanilla
    A chain of residues connecting the voltage sensing domain and the pore domain is responsible for a noncanonical communication between these domains.
    1. Plant Biology

    Functional diversification gave rise to allelic specialization in a rice NLR immune receptor pair

    Juan Carlos De la Concepcion, Javier Vega Benjumea ... Mark J Banfield
    Biochemical and in planta studies reveal how a rice immune receptor pair has coevolved to deliver immune responses, an important step towards understanding and engineering bespoke resistance to crop pathogens that threaten food security.
    1. Biochemistry and Chemical Biology

    Allosteric mechanism of signal transduction in the two-component system histidine kinase PhoQ

    Bruk Mensa, Nicholas F Polizzi ... William F DeGrado
    Mutations along the signaling pathway of the E. coli sensor histidine kinase PhoQ alter signal gain and ligand-sensitivity by altering thermodynamic allosteric coupling between domains.
    1. Neuroscience

    Targeted sensors for glutamatergic neurotransmission

    Yuchen Hao, Estelle Toulmé ... Andrew JR Plested
    Targeting a genetically-encoded glutamate sensor to postsynaptic sites demonstrates the feasibility of simultaneous optical quantal analysis of many inputs to a neuron in wide-field fluorescence microscopy.
    1. Cell Biology
    2. Developmental Biology

    Global analysis of cell behavior and protein dynamics reveals region-specific roles for Shroom3 and N-cadherin during neural tube closure

    Austin T Baldwin, Juliana H Kim ... John B Wallingford
    Tissue-level cell tracking and analysis of actomyosin and N-cadherin adhesion dynamics, coupled with disruption of the regulatory gene Shroom3, reveals region-specific cell behaviors along the anteroposterior axis during neural tube closure.

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