12,080 results found
    1. Neuroscience

    Postural control of arm and fingers through integration of movement commands

    Scott T Albert, Alkis M Hadjiosif ... Reza Shadmehr
    After a movement, the final posture of the arm is stabilized by a subcortical structure that mathematically integrates movement commands over time.
    1. Developmental Biology
    2. Genetics and Genomics

    Efficient targeted integration directed by short homology in zebrafish and mammalian cells

    Wesley A Wierson, Jordan M Welker ... Jeffrey Essner
    Short homology arms exposed by CRISPR/Cas9 cleavage can target integration at genomic CRISPR/Cas9 cut sites at high frequencies with reproducible precision using pGTag vectors in zebrafish and mammalian cells.
    1. Neuroscience

    Influence of sensory modality and control dynamics on human path integration

    Akis Stavropoulos, Kaushik J Lakshminarasimhan ... Dora E Angelaki
    Human path integration accuracy is strongly influenced by the underlying control dynamics, but less so when visual, rather than vestibular, feedback is available.
    1. Structural Biology and Molecular Biophysics

    A bend, flip and trap mechanism for transposon integration

    Elizabeth R Morris, Heather Grey ... Julia M Richardson
    Structural and biochemical analyses of a eukaryotic DNA transpososome in the integration step reveal how mariner/Tc1 transposons are selectively integrated into a TA target sequence.
    1. Computational and Systems Biology

    The genetic landscape of a physical interaction

    Guillaume Diss, Ben Lehner
    First comprehensive analysis of how many different mutations combine within and between two genes to alter a molecular phenotype.
    1. Neuroscience

    Emotional learning retroactively promotes memory integration through rapid neural reactivation and reorganization

    Yannan Zhu, Yimeng Zeng ... Shaozheng Qin
    Emotional learning retroactively promotes memory integration for previously neutral events into episodic memory to foster future event predictions, through rapidly stimulating trial-specific reactivation of overlapping memory traces and reorganization of associated memories among the amygdala, hippocampal, and neocortical circuits.
    1. Neuroscience

    Integrative frontal-parietal dynamics supporting cognitive control

    Derek Evan Nee
    Analysis of human fMRI data reveal that intermediary areas within the fronto-parietal control network (FPCN) are critical for integrating control processing, cognitive ability, and amenability to neuromodulation.
    1. Neuroscience

    Inter- and intra-animal variation in the integrative properties of stellate cells in the medial entorhinal cortex

    Hugh Pastoll, Derek L Garden ... Matthew F Nolan
    Setpoints that determine the integrative properties of neurons in the medial entorhinal cortex are established at a population level and differ between animals.
    1. Neuroscience

    Energy exchanges at contact events guide sensorimotor integration

    Ali Farshchian, Alessandra Sciutti ... Ferdinando A Mussa-Ivaldi
    The brain obtains and preserves a consistent temporal alignment of multisensory and motor information flowing along staggered streams by maintaining an invariant estimate across modalities of the energy exchanged with the environment at discrete events.
    1. Neuroscience
    2. Microbiology and Infectious Disease

    Social interaction-induced activation of RNA splicing in the amygdala of microbiome-deficient mice

    Roman M Stilling, Gerard M Moloney ... John F Cryan
    Social-interaction impairment in germ-free mice is associated with a markedly altered transcriptional response to social novelty in the amygdala, as characterised by replacement of upregulation of common stimulus-induced pathways with upregulation of the splicing machinery.

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