791 results found
    1. Neuroscience

    Synchronized excitability in a network enables generation of internal neuronal sequences

    Yingxue Wang, Zachary Roth, Eva Pastalkova
    Hippocampal sharp-wave sequences, which are considered the key phenomenon underlying consolidation of episodic memory, are preserved even after an animal’s memory is impaired.
    1. Cell Biology

    Different translation dynamics of β- and γ-actin regulates cell migration

    Pavan Vedula, Satoshi Kurosaka ... Anna Kashina
    β- and γ-cytoplasmic actins have different translation rates in cells and exert different nucleotide coding sequence-dependent effects on cell migration.
    1. Chromosomes and Gene Expression

    Six domesticated PiggyBac transposases together carry out programmed DNA elimination in Paramecium

    Julien Bischerour, Simran Bhullar ... Mireille Bétermier
    The machinery that carries out programmed DNA rearrangements is composed of domesticated transposases. One is catalytically active, five play architectural function essential for the accuracy of the process.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Structure of the germline genome of Tetrahymena thermophila and relationship to the massively rearranged somatic genome

    Eileen P Hamilton, Aurélie Kapusta ... Robert S Coyne
    The model organism Tetrahymena thermopile carries two nuclei with distinct genomes: an unrearranged germline genome with five chromosomes, and a somatic genome reduced in size by a third and with 181 chromosomes.
    1. Neuroscience

    A suppression hierarchy among competing motor programs drives sequential grooming in Drosophila

    Andrew M Seeds, Primoz Ravbar ... Julie H Simpson
    Gaining genetic control over neural modules that drive the grooming of each Drosophila body part reveals how mechanisms for selecting among competing behavioral choices are used to generate sequences of actions.
    1. Neuroscience

    Rigid firing sequences undermine spatial memory codes in a neurodegenerative mouse model

    Jingheng Cheng, Daoyun Ji
    In a mouse model of neurodegeneration, hippocampal firing sequences that normally encode spatial memories become disengaged from external space.
    1. Chromosomes and Gene Expression

    Assessing long-distance RNA sequence connectivity via RNA-templated DNA–DNA ligation

    Christian K Roy, Sara Olson ... Melissa J Moore
    SeqZip is a new DNA ligation-based method to condense and maintain exon connectivity information within individual RNA molecules, which can provide new insights into alternative splicing.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Comprehensive mapping of adaptation of the avian influenza polymerase protein PB2 to humans

    YQ Shirleen Soh, Louise H Moncla ... Jesse D Bloom
    Complete mapping of human-adaptive mutations to the avian influenza PB2 protein shows how selection at key molecular interfaces combines with evolutionary accessibility to shape viral host adaptation.
    1. Chromosomes and Gene Expression
    2. Physics of Living Systems

    DNA sequence encodes the position of DNA supercoils

    Sung Hyun Kim, Mahipal Ganji ... Cees Dekker
    Single-molecule experiments reveal that plectonemic supercoils occupy specific positions on DNA and a physical model relates this to the intrinsic curvature, providing an insight into how supercoiling organizes the genome.

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